Bioactivity: Measured by its ability to induce alkaline phosphatase production by C3H10T1/2 mouse embryonic fibroblast cells. The ED50 for this effect is 0.6-3 µg/mL.
Endotoxin Concentration: <0.1 EU/μg
Item Number
rp154674
Grouped product items
SKU
Size
Availability
Price
Qty
rp154674-10μg
10μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$89.90
rp154674-50μg
50μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
Recombinant Mouse Sonic Hedgehog/Shh Protein, ≥95% (SDS-PAGE), high purity
Synonyms
HHG1 | HHG-1 | HLP3 | HPE3 | MCOPCB5 | sonic hedgehog (Drosophila) homolog | Shh | ShhNC | SMMCI | sonic hedgehog homolog (Drosophila) | sonic hedgehog protein | sonic hedgehog homolog | Sonic Hedgehog | TPT | TPTPS | Hx | Dsh | Hxl3 | M100081 | 9530036O1
Grade
ActiBioPure™, Animal Free, Azide Free, Bioactive, Carrier Free, High Performance
Product Description
Purity ≥95% SDS-PAGE. Endotoxin level <0.1 EU/µg Function Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction.
Measured by its ability to induce alkaline phosphatase production by C3H10T1/2 mouse embryonic fibroblast cells. The ED50 for this effect is 0.6-3 µg/mL.
