A synthetic peptide derived from human NUDEL (AA 1-36)
Positive Control
WB: HeLa, Jurkat, HEK293, A549, RAW 264.7 and C6 cell lysates.
Conjugation
Unconjugated
Grade
ExactAb™, KD验证, Recombinant, Validated
Product Description
Rabbit anti Human NDEL1 Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/2000 Protein Function: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.
Product Properties
Isotype
Rabbit IgG
Light Chain Type
kappa
SDS-PAGE
150 kDa
Purification Method
Protein A purified
Form
Liquid
Concentration
Lot by Lot
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
Images
Recombinant NDEL1 Antibody (Ab117292) - Western Blot All lanes: Recombinant NDEL1 Antibody (Ab117292) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 40 kDa Observed band size: 42 kDa Exposure time: 60.0 s
Associated Targets
NDEL1Tbio Nuclear distribution protein nudE-like 1 0 Activities