Skip to the beginning of the images gallery

Recombinant Neuropilin 1 Antibody - Primary antibody, specific to NRP1, Rabbit IgG

ExactAb™
Recombinant
Validated
0.8 mg/mL

Features and benefits

Short Overview:
Recombinant; Rabbit anti Human Neuropilin 1 Antibody; WB; Unconjugated
Species reactivity(Reacts with): Human,Mouse,Rat
Isotype: Rabbit IgG

Application:

Item Number

Ab117770

Grouped product items
SKU	Size	Availability	Price
Ab117770-10μl	10μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$69.90
Ab117770-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$199.90
Ab117770-50μl	50μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	Special Price $199.90 Regular Price $299.90
Ab117770-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,699.90

Recombinant; Rabbit anti Human Neuropilin 1 Antibody; WB; Unconjugated

View related series

Accession#:O14786 Gene ID:8829 neuropilin 1 NRP1

Basic Description

Product Name	Recombinant Neuropilin 1 Antibody - Primary antibody, specific to NRP1, Rabbit IgG
Synonyms	BDCA4 \| BDCA-4 \| CD304 antigen \| CD304 \| DKFZp686A03134 \| DKFZp781F1414 \| neuropilin 1 \| Neuropilin1 \| Neuropilin-1 \| NP1 \| NRP \| NRP1 \| transmembrane receptor \| Vascular endothelial cell growth factor 165 receptor \| VEGF165R \| A5 protein antibody \| BDCA4
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.8 mg/mL
Host species	Rabbit
Specificity	NRP1
Immunogen	A synthetic peptide derived from human Neuropilin 1 (AA 900-923)
Positive Control	WB: A549, Mouse heart, Rat heart lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human Neuropilin 1 Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/1000 Protein Function The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Product Properties

Isotype	Rabbit IgG
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	0.8 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Application

Dilution info

1/500-1/1000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0606706	Certificate of Analysis	Jun 11, 2024	Ab117770
ZJ24F0606705	Certificate of Analysis	Jun 11, 2024	Ab117770

References

1. Powell J, Mota F, Steadman D, Soudy C, Miyauchi JT, Crosby S, Jarvis A, Reisinger T, Winfield N, Evans G et al.. (2018) Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells.. J Med Chem, 61 (9): (4135-4154). [PMID:29648813]
2. Davies J, Randeva HS, Chatha K, Hall M, Spandidos DA, Karteris E, Kyrou I. (2020) Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19.. Mol Med Rep, 22 (5): (4221-4226). [PMID:33000221]
3. Teesalu T, Sugahara KN, Kotamraju VR, Ruoslahti E. (2009) C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration.. Proc Natl Acad Sci U S A, 106 (38): (16157-62). [PMID:19805273]
4. Jarvis A, Allerston CK, Jia H, Herzog B, Garza-Garcia A, Winfield N, Ellard K, Aqil R, Lynch R, Chapman C et al.. (2010) Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.. J Med Chem, 53 (5): (2215-26). [PMID:20151671]
5. Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Antón-Plágaro C, Shoemark DK, Simón-Gracia L, Bauer M, Hollandi R et al.. (2020) Neuropilin-1 is a host factor for SARS-CoV-2 infection.. Science, 370 (6518): (861-865). [PMID:33082294]
6. Tymecka D, Puszko AK, Lipiński PFJ, Fedorczyk B, Wilenska B, Sura K, Perret GY, Misicka A.. (2018) Branched pentapeptides as potent inhibitors of the vascular endothelial growth factor 165 binding to Neuropilin-1: Design, synthesis and biological activity.. Eur J Med Chem, 158 (453-462). [PMID:30241012]
7. He, Z Z and Tessier-Lavigne, M M.. (1997) Neuropilin is a receptor for the axonal chemorepellent Semaphorin III.. Cell, (22): [PMID:9288753]
8. Soker, S S, Takashima, S S, Miao, H Q HQ, Neufeld, G G and Klagsbrun, M M.. (1998) Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.. Cell, (20): [PMID:9529250]
9. Tamagnone, L L and 11 more authors.. (1999) Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.. Cell, (1): [PMID:10520995]
10. Gagnon, M L ML and 6 more authors.. (2000) Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity.. Proceedings of the National Academy of Sciences of the United States of America, (14): [PMID:10688880]
11. Gluzman-Poltorak, Z Z, Cohen, T T, Herzog, Y Y and Neufeld, G G.. (2000) Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected].. The Journal of biological chemistry, (16): [PMID:10748121]
12. Lee, Christian C CC, Kreusch, Andreas A, McMullan, Daniel D, Ng, Ken K and Spraggon, Glen G.. (2003) Crystal structure of the human neuropilin-1 b1 domain.. Structure (London, England : 1993), [PMID:12517344]
13. Deloukas, P P and 135 more authors.. (2004) The DNA sequence and comparative analysis of human chromosome 10.. Nature, (27): [PMID:15164054]
14. Liu, Tao T and 6 more authors.. () Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.. Journal of proteome research, [PMID:16335952]
15. Shintani, Yasunori Y and 12 more authors.. (2006) Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling.. The EMBO journal, (12): [PMID:16763549]
16. Appleton, Brent A BA and 16 more authors.. (2007) Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding.. The EMBO journal, (28): [PMID:17989695]
17. He, Weiwei W and 16 more authors.. (2015) CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.. Nature, (29): [PMID:26503042]
18. Issitt, Theo and 8 more authors.. (2019) Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress.. iScience, (25): [PMID:30623799]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Recombinant Neuropilin 1 Antibody - Primary antibody, specific to NRP1, Rabbit IgG

Basic Description

Product Properties

Associated Targets

NRP1 Tchem Neuropilin-1 0 Activities