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Recombinant PRMT5 Antibody - Primary antibody, specific to PRMT5, Rabbit IgG

ExactAb™
Recombinant
Validated
0.8 mg/mL

Features and benefits

Short Overview:
Recombinant; Rabbit anti Human PRMT5 Antibody; WB; Unconjugated
Species reactivity(Reacts with): Human,Mouse,Rat
Isotype: Rabbit IgG

Application:

Item Number

Ab123105

Grouped product items
SKU	Size	Availability	Price
Ab123105-10μl	10μl	In stock	$66.90
Ab123105-50μl	50μl	In stock	$189.90
Ab123105-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$299.90
Ab123105-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,599.90

Recombinant; Rabbit anti Human PRMT5 Antibody; WB; Unconjugated

View related series

Accession#:O14744 Gene ID:10419 PRMT5

Basic Description

Product Name	Recombinant PRMT5 Antibody - Primary antibody, specific to PRMT5, Rabbit IgG
Synonyms	HRMT1L5 \| HSL7 \| IBP72 \| JBP1 \| SKB1 \| SKB1Hs72 kDa ICln binding protein antibody \| 72 kDa ICln-binding protein antibody \| ANM5_HUMAN antibody \| Histone synthetic lethal 7, S. cerevisiae, homolog of antibody \| Histone-arginine N-methyltransferase PRMT5 an
Specifications & Purity	ExactAb™, Validated, Recombinant, 0.8 mg/mL
Host species	Rabbit
Specificity	PRMT5
Immunogen	A synthetic peptide derived from human PRMT5 (AA 40-92)
Positive Control	WB: Hep G2, HeLa, A549, HEK293, Jurkat, A431, NIH/3T3 and C6 cell lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human PRMT5 Antibody, Recombinant, could be used for WB and soon. Application: WB: 1/500-1/1000 Protein Function: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10.

Product Properties

Isotype	Rabbit IgG
Light Chain Type	kappa
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	0.8 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant PRMT5 Antibody (Ab123105) - Western Blot
All lanes: Recombinant PRMT5 Antibody (Ab123105) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 73 kDa
Observed band size: 70 kDa
Exposure time: 11.1 s

Associated Targets

PRMT5 Tchem Protein arginine N-methyltransferase 5 0 Activities

Discover Target: PRMT5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Application

Application	Dilution info
WB	1/500-1/1000

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0505727	Certificate of Analysis	May 16, 2024	Ab123105
ZJ24F0505726	Certificate of Analysis	May 16, 2024	Ab123105

References

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36. Krapivinsky, G G, Pu, W W, Wickman, K K, Krapivinsky, L L and Clapham, D E DE.. (1998) pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology.. The Journal of biological chemistry, (1): [PMID:9556550]
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39. Schwärzler, A A, Kreienkamp, H J HJ and Richter, D D.. (2000) Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast.. The Journal of biological chemistry, (31): [PMID:10734105]
40. Rho, J J and 5 more authors.. (2001) Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family.. The Journal of biological chemistry, (6): [PMID:11152681]
41. Fabbrizio, Eric E and 10 more authors.. (2002) Negative regulation of transcription by the type II arginine methyltransferase PRMT5.. EMBO reports, [PMID:12101096]
42. Meister, Gunter G and Fischer, Utz U.. (2002) Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs.. The EMBO journal, (1): [PMID:12411503]
43. Heilig, Roland R and 98 more authors.. (2003) The DNA sequence and analysis of human chromosome 14.. Nature, (6): [PMID:12508121]
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45. Kwak, Youn Tae YT and 7 more authors.. (2003) Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties.. Molecular cell, [PMID:12718890]
46. Pal, Sharmistha S, Vishwanath, Sheethal N SN, Erdjument-Bromage, Hediye H, Tempst, Paul P and Sif, Saïd S.. (2004) Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.. Molecular and cellular biology, [PMID:15485929]
47. Jiang, Wei W, Roemer, Martha E ME and Newsham, Irene F IF.. (2005) The tumor suppressor DAL-1/4.1B modulates protein arginine N-methyltransferase 5 activity in a substrate-specific manner.. Biochemical and biophysical research communications, (8): [PMID:15737618]
48. Azzouz, Teldja N TN and 7 more authors.. (2005) Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.. The Journal of biological chemistry, (14): [PMID:16087681]
49. Le Guezennec, Xavier X and 6 more authors.. (2006) MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.. Molecular and cellular biology, [PMID:16428440]
50. Liu, Zhangguo Z, Zhou, Zhongwei Z, Chen, Guohong G and Bao, Shilai S.. (2007) A putative transcriptional elongation factor hIws1 is essential for mammalian cell proliferation.. Biochemical and biophysical research communications, (2): [PMID:17184735]
51. Gonsalvez, Graydon B GB and 5 more authors.. (2007) Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins.. The Journal of cell biology, (27): [PMID:17709427]
52. Lacroix, Matthieu M and 5 more authors.. (2008) The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5.. EMBO reports, [PMID:18404153]
53. Chari, Ashwin A and 8 more authors.. (2008) An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs.. Cell, (31): [PMID:18984161]
54. Jansson, Martin M and 6 more authors.. (2008) Arginine methylation regulates the p53 response.. Nature cell biology, [PMID:19011621]
55. Goshima, Naoki N and 54 more authors.. (2008) Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.. Nature methods, [PMID:19054851]
56. Ren, Jinqi J and 5 more authors.. (2010) Methylation of ribosomal protein S10 by protein-arginine methyltransferase 5 regulates ribosome biogenesis.. The Journal of biological chemistry, (23): [PMID:20159986]
57. Zhou, Zhongwei Z and 12 more authors.. (2010) PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130.. Cell research, [PMID:20421892]
58. Guo, Shaoshi S and Bao, Shilai S.. (2010) srGAP2 arginine methylation regulates cell migration and cell spreading through promoting dimerization.. The Journal of biological chemistry, (5): [PMID:20810653]
59. Guderian, Gernot G and 6 more authors.. (2011) RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity.. The Journal of biological chemistry, (21): [PMID:21081503]
60. Hsu, Jung-Mao JM and 14 more authors.. (2011) Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation.. Nature cell biology, [PMID:21258366]
61. Andreu-Pérez, Pedro P and 10 more authors.. (2011) Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.. Science signaling, (13): [PMID:21917714]
62. Bienvenut, Willy V WV and 6 more authors.. (2012) Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-α-acetylation features.. Molecular & cellular proteomics : MCP, [PMID:22223895]
63. Bandyopadhyay, Smarajit S and 9 more authors.. (2012) HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules.. Molecular and cellular biology, [PMID:22269951]
64. Van Damme, Petra P and 15 more authors.. (2012) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.. Proceedings of the National Academy of Sciences of the United States of America, (31): [PMID:22814378]
65. Antonysamy, Stephen S and 16 more authors.. (2012) Crystal structure of the human PRMT5:MEP50 complex.. Proceedings of the National Academy of Sciences of the United States of America, (30): [PMID:23071334]
66. Ju, Junyi J and 14 more authors.. (2014) Human fetal globin gene expression is regulated by LYAR.. Nucleic acids research, [PMID:25092918]
67. Takai, Hiroki H and 19 more authors.. (2014) 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.. Cell reports, (9): [PMID:25284789]
68. Zhao, Dorothy Yanling DY and 14 more authors.. (2016) SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.. Nature, (7): [PMID:26700805]
69. Qi, Wei W and 39 more authors.. (2017) An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.. Nature chemical biology, [PMID:28135235]
70. Chakrapani, Baskar and 10 more authors.. (2021) The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions.. Life science alliance, [PMID:33376131]

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