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Recombinant RAGE Antibody

ExactAb™
Recombinant
Validated
Lot by Lot

Features and benefits

Short Overview:
Recombinant; Rabbit anti Human RAGE Antibody; WB; Unconjugated
Species reactivity(Reacts with): Human,Mouse,Rat
Isotype: Rabbit IgG

Application:

Item Number

Ab124452

Grouped product items
SKU	Size	Availability	Price
Ab124452-10μl	10μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$59.90
Ab124452-50μl	50μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$169.90
Ab124452-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$269.90
Ab124452-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,099.90

Recombinant; Rabbit anti Human RAGE Antibody; WB; Unconjugated

View related series

Accession#:Q15109 AGER Gene ID:177 RAGE

Basic Description

Product Name	Recombinant RAGE Antibody
Specifications & Purity	ExactAb™, Validated, Recombinant, Lot by Lot
Host species	Rabbit
Specificity	RAGE
Immunogen	A synthetic peptide derived from human RAGE (AA 344-404).
Positive Control	WB: Mouse lung and Rat lung lysates.
Conjugation	Unconjugated
Grade	ExactAb™, Recombinant, Validated
Product Description	Rabbit anti Human RAGE Antibody, Recombinant, could be used for WB and so on. Application: WB: 1/500-1/2000 Protein Function： Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.

Isotype

Rabbit IgG

Light Chain Type

kappa

SDS-PAGE

150 kDa

Purification Method

Protein A purifie

Form

Liquid

Concentration

Lot by Lot

Storage Temp

Store at -20°C,Avoid repeated freezing and thawing

Shipped In

Ice chest + Ice pads

Stability And Storage

WB: Mouse lung lysates.

Images

Recombinant RAGE Antibody (Ab124452) - Western Blot
All lanes: Recombinant RAGE Antibody (Ab124452) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution

Predicted band size: 43 kDa
Observed band size: 48 kDa
Exposure time: 25.9 s

Application

Dilution info

1/500-1/2000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0708447	Certificate of Analysis	Jul 17, 2024	Ab124452
ZJ24F0708446	Certificate of Analysis	Jul 17, 2024	Ab124452

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Recombinant RAGE Antibody

Basic Description

Product Properties

Images

Associated Targets

AGER Tchem Advanced glycosylation end product-specific receptor 0 Activities