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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Recombinant; Rabbit anti Human SESN2/Sestrin-2 Antibody; WB, IF, ICC; Unconjugated
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
Ab127226-10μl | 10μl | In stock | $69.90 | |
Ab127226-50μl | 50μl | In stock | $199.90 | |
Ab127226-100μl | 100μl | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $309.90 | |
Ab127226-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,699.90 |
Recombinant; Rabbit anti Human SESN2/Sestrin-2 Antibody; WB, IF, ICC; Unconjugated
Product Name | Recombinant SESN2/Sestrin-2 Antibody - Primary antibody, specific to SESN2, Rabbit IgG |
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Synonyms | HI95; SES2; SEST2; DKFZp761M0212 antibody; DKFZp761M02121 antibody; Hi95 antibody; Hypoxia induced gene 95 antibody; MGC11758 antibody; OTTHUMP00000003641 antibody; OTTMUSP00000010184 antibody; RP23 63D8.3 antibody; SES2 antibody; SESN 2 antibody; SESN2 a |
Specifications & Purity | ExactAb™, Validated, Recombinant, 0.8 mg/mL |
Host species | Rabbit |
Specificity | SESN2 |
Immunogen | Recombinant protein of human SESN2 (AA 131-480) |
Positive Control | WB: K562, C6, Mouse spleen lysates. ICC/IF: HeLa cells. |
Conjugation | Unconjugated |
Grade | ExactAb™, Recombinant, Validated |
Product Description |
Rabbit anti Human SESN2/Sestrin-2 Antibody, Recombinant, could be used for WB, IF, ICC and so on. |
Isotype | Rabbit IgG |
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SDS-PAGE | 150 kDa |
Purification Method | Immunogen affinity purified |
Form | Liquid |
Concentration | 0.8 mg/mL |
Storage Temp | Store at -20°C,Avoid repeated freezing and thawing |
Shipped In | Ice chest + Ice pads |
Stability And Storage | Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Application | Dilution info |
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WB | 1/500-1/1000 |
ICC/IF |
1/50-1/200
|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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ZJ24F0505573 | Certificate of Analysis | May 14, 2024 | Ab127226 |
ZJ24F0505572 | Certificate of Analysis | May 14, 2024 | Ab127226 |
1. Wiemann, S S and 23 more authors.. (2001) Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.. Genome research, [PMID:11230166] |
2. Budanov, Andrei V AV and 13 more authors.. (2002) Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability.. Oncogene, (5): [PMID:12203114] |
3. Peeters, H H and 11 more authors.. (2003) PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.. Human genetics, [PMID:12607115] |
4. Budanov, Andrei V AV, Sablina, Anna A AA, Feinstein, Elena E, Koonin, Eugene V EV and Chumakov, Peter M PM.. (2004) Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.. Science (New York, N.Y.), (23): [PMID:15105503] |
5. Gregory, S G SG and 178 more authors.. (2006) The DNA sequence and biological annotation of human chromosome 1.. Nature, (18): [PMID:16710414] |
6. Budanov, Andrei V AV and Karin, Michael M.. (2008) p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.. Cell, (8): [PMID:18692468] |
7. Woo, Hyun Ae HA, Bae, Soo Han SH, Park, Sunjoo S and Rhee, Sue Goo SG.. (2009) Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.. Antioxidants & redox signaling, [PMID:19113821] |
8. Van Damme, Petra P and 15 more authors.. (2012) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.. Proceedings of the National Academy of Sciences of the United States of America, (31): [PMID:22814378] |
9. Bae, Soo Han SH and 8 more authors.. (2013) Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.. Cell metabolism, (8): [PMID:23274085] |
10. Park, Hwan-Woo HW and 10 more authors.. (2014) Hepatoprotective role of Sestrin2 against chronic ER stress.. Nature communications, (20): [PMID:24947615] |
11. Ro, Seung-Hyun SH and 7 more authors.. (2014) Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.. The FEBS journal, [PMID:25040165] |
12. Peng, Min M, Yin, Na N and Li, Ming O MO.. (2014) Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.. Cell, (25): [PMID:25259925] |
13. Chantranupong, Lynne L and 9 more authors.. (2014) The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.. Cell reports, (9): [PMID:25263562] |
14. Parmigiani, Anita A and 8 more authors.. (2014) Sestrins inhibit mTORC1 kinase activation through the GATOR complex.. Cell reports, (20): [PMID:25457612] |
15. Wolfson, Rachel L RL and 6 more authors.. (2016) Sestrin2 is a leucine sensor for the mTORC1 pathway.. Science (New York, N.Y.), (1): [PMID:26449471] |
16. Saxton, Robert A RA and 7 more authors.. (2016) Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.. Science (New York, N.Y.), (1): [PMID:26586190] |
17. Kim, Hanseong H and 10 more authors.. (2015) Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.. Nature communications, (27): [PMID:26612684] |