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Recombinant SESN2/Sestrin-2 Antibody - Primary antibody, specific to SESN2, Rabbit IgG

  • ExactAb™
  • Recombinant
  • Validated
  • 0.8 mg/mL
Features and benefits
  • Short Overview:

    Recombinant; Rabbit anti Human SESN2/Sestrin-2 Antibody; WB, IF, ICC; Unconjugated

  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Rabbit IgG
    Application:
  • IF/ICC
  • WB
Item Number
Ab127226
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab127226-10μl
10μl
In stock
$69.90
Ab127226-50μl
50μl
In stock
$199.90
Ab127226-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$309.90
Ab127226-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90

Recombinant; Rabbit anti Human SESN2/Sestrin-2 Antibody; WB, IF, ICC; Unconjugated

Basic Description

Product NameRecombinant SESN2/Sestrin-2 Antibody - Primary antibody, specific to SESN2, Rabbit IgG
SynonymsHI95; SES2; SEST2; DKFZp761M0212 antibody; DKFZp761M02121 antibody; Hi95 antibody; Hypoxia induced gene 95 antibody; MGC11758 antibody; OTTHUMP00000003641 antibody; OTTMUSP00000010184 antibody; RP23 63D8.3 antibody; SES2 antibody; SESN 2 antibody; SESN2 a
Specifications & PurityExactAb™, Validated, Recombinant, 0.8 mg/mL
Host speciesRabbit
SpecificitySESN2
ImmunogenRecombinant protein of human SESN2 (AA 131-480)
Positive ControlWB: K562, C6, Mouse spleen lysates. ICC/IF: HeLa cells.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human SESN2/Sestrin-2 Antibody, Recombinant, could be used for WB, IF, ICC and so on.
Application:
WB: 1/500-1/1000
ICC/IF: 1/50-1/200

Product Properties

IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodImmunogen affinity purified
FormLiquid
Concentration0.8 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets

SESN2 Tbio Sestrin-2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
WB

1/500-1/1000

ICC/IF

1/50-1/200

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0505573Certificate of AnalysisMay 14, 2024 Ab127226
ZJ24F0505572Certificate of AnalysisMay 14, 2024 Ab127226

Related Documents

References

1. Wiemann, S S and 23 more authors..  (2001)  Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs..  Genome research,      [PMID:11230166]
2. Budanov, Andrei V AV and 13 more authors..  (2002)  Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability..  Oncogene,    (5):   [PMID:12203114]
3. Peeters, H H and 11 more authors..  (2003)  PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse..  Human genetics,      [PMID:12607115]
4. Budanov, Andrei V AV, Sablina, Anna A AA, Feinstein, Elena E, Koonin, Eugene V EV and Chumakov, Peter M PM..  (2004)  Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD..  Science (New York, N.Y.),    (23):   [PMID:15105503]
5. Gregory, S G SG and 178 more authors..  (2006)  The DNA sequence and biological annotation of human chromosome 1..  Nature,    (18):   [PMID:16710414]
6. Budanov, Andrei V AV and Karin, Michael M..  (2008)  p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling..  Cell,    (8):   [PMID:18692468]
7. Woo, Hyun Ae HA, Bae, Soo Han SH, Park, Sunjoo S and Rhee, Sue Goo SG..  (2009)  Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins..  Antioxidants & redox signaling,      [PMID:19113821]
8. Van Damme, Petra P and 15 more authors..  (2012)  N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB..  Proceedings of the National Academy of Sciences of the United States of America,    (31):   [PMID:22814378]
9. Bae, Soo Han SH and 8 more authors..  (2013)  Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage..  Cell metabolism,    (8):   [PMID:23274085]
10. Park, Hwan-Woo HW and 10 more authors..  (2014)  Hepatoprotective role of Sestrin2 against chronic ER stress..  Nature communications,    (20):   [PMID:24947615]
11. Ro, Seung-Hyun SH and 7 more authors..  (2014)  Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1..  The FEBS journal,      [PMID:25040165]
12. Peng, Min M, Yin, Na N and Li, Ming O MO..  (2014)  Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling..  Cell,    (25):   [PMID:25259925]
13. Chantranupong, Lynne L and 9 more authors..  (2014)  The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1..  Cell reports,    (9):   [PMID:25263562]
14. Parmigiani, Anita A and 8 more authors..  (2014)  Sestrins inhibit mTORC1 kinase activation through the GATOR complex..  Cell reports,    (20):   [PMID:25457612]
15. Wolfson, Rachel L RL and 6 more authors..  (2016)  Sestrin2 is a leucine sensor for the mTORC1 pathway..  Science (New York, N.Y.),    (1):   [PMID:26449471]
16. Saxton, Robert A RA and 7 more authors..  (2016)  Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway..  Science (New York, N.Y.),    (1):   [PMID:26586190]
17. Kim, Hanseong H and 10 more authors..  (2015)  Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains..  Nature communications,    (27):   [PMID:26612684]

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