Click Here for 5% Off Your First Aladdin Purchase!

Recombinant SHP1 Antibody - Primary antibody, specific to PTPN6, Rabbit IgG

  • ExactAb™
  • Recombinant
  • Validated
  • 0.3 mg/mL
Features and benefits
  • Short Overview:

    Recombinant; Rabbit anti Human SHP1 Antibody; WB, IHC; Unconjugated

  • Species reactivity(Reacts with): Human
  • Isotype: Rabbit IgG
    Application:
  • IHC
  • WB
Item Number
Ab127501
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab127501-10μl
10μl
In stock
$66.90
Ab127501-50μl
50μl
In stock
$189.90
Ab127501-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$299.90
Ab127501-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,699.90

Recombinant; Rabbit anti Human SHP1 Antibody; WB, IHC; Unconjugated

Basic Description

Product NameRecombinant SHP1 Antibody - Primary antibody, specific to PTPN6, Rabbit IgG
SynonymsHCP; HCPH; HPTP1C; PTP1C; PTP-1C; PTPN6; SHP1; SHP-1; SHP-1L; SH-PTP1; 70Z-SHP antibody; EC 3.1.3.48 antibody; HCP antibody; HCPH antibody; Hematopoietic cell phosphatase antibody; Hematopoietic cell protein tyrosine phosphatase antibody; Hematopoietic ce
Specifications & PurityExactAb™, Validated, Recombinant, 0.3 mg/mL
Host speciesRabbit
SpecificityPTPN6
ImmunogenA synthetic peptide derived from human SHP1 (AA 2-20)
Positive ControlWB: Jurkat, Raji and MCF7 cell lysates. IHC: Human tonsil tissue.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human SHP1 Antibody, Recombinant, could be used for WB, IHC and so on.
Application:
WB: 1/500-1/1000
IHC: 1/50-1/100
Protein Function:
Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.

Product Properties

IsotypeRabbit IgG
SDS-PAGE150 kDa
Purification MethodAntigen affinity purified
FormLiquid
Concentration0.3 mg/mL
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Images

Recombinant SHP1 Antibody (Ab127501) - Western Blot
All lanes: Recombinant SHP1 Antibody (Ab127501) at 1/1000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/30000 dilution

Predicted band size: 67 kDa
Observed band size: 56, 65 kDa
Exposure time: 17.1 s


Recombinant SHP1 Antibody (Ab127501) - IHC
Immunohistochemistry analysis of paraffin-embedded Human tonsil using Recombinant SHP1 Antibody (Ab127501). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Associated Targets

PTPN6 Tchem Tyrosine-protein phosphatase non-receptor type 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Application

ApplicationDilution info
WB

1/500-1/1000

IHC

1/50 - 1/100

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

2 results found

Lot NumberCertificate TypeDateItem
ZJ24F0102377Certificate of AnalysisJan 10, 2024 Ab127501
ZJ24F0102376Certificate of AnalysisJan 08, 2024 Ab127501

Related Documents

References

1. He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N et al..  (2013)  A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases..  J Med Chem,  56  (12): (4990-5008).  [PMID:23713581]
2. Angst D, Gessier F, Janser P, Vulpetti A, Wälchli R, Beerli C, Littlewood-Evans A, Dawson J, Nuesslein-Hildesheim B, Wieczorek G et al..  (2020)  Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase..  J Med Chem,  63  (10): (5102-5118).  [PMID:32083858]
3. Latanya M Scott,Liwei Chen,Kenyon G Daniel,Wesley H Brooks,Wayne C Guida,Harshani R Lawrence,Said M Sebti,Nicholas J Lawrence,Jie Wu.  (2011-01-05)  Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs..  Bioorganic & medicinal chemistry letters,  21  ((2)): (730-733).  [PMID:21193311]
4. Suja Shrestha,Bharat Raj Bhattarai,Keun-Hyeung Lee,Hyeongjin Cho.  (2007-08-19)  Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs..  Bioorganic & medicinal chemistry,  15  ((20)): (6535-6548).  [PMID:17692525]
5. Yi-Nan Zhang,Wei Zhang,Di Hong,Lei Shi,Qiang Shen,Jing-Ya Li,Jia Li,Li-Hong Hu.  (2008-08-19)  Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities..  Bioorganic & medicinal chemistry,  16  ((18)): (8697-8705).  [PMID:18707891]
6. Hai-Bing He,Li-Xin Gao,Qi-Feng Deng,Wei-Ping Ma,Chun-Lan Tang,Wen-Wei Qiu,Jie Tang,Jing-Ya Li,Jia Li,Fan Yang.  (2012-10-17)  Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B..  Bioorganic & medicinal chemistry letters,  22  ((23)): (7237-7242).  [PMID:23067554]
7. Shrestha S, Bhattarai BR, Chang KJ, Lee KH, Cho H..  (2007)  Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity..  Bioorg Med Chem Lett,  17  (10): (2760-2764).  [PMID:17368023]
8. Lawrence HR, Pireddu R, Chen L, Luo Y, Sung SS, Szymanski AM, Yip ML, Guida WC, Sebti SM, Wu J, Lawrence NJ..  (2008)  Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds..  J Med Chem,  51  (16): (4948-4956).  [PMID:18680359]
9. Shrestha S, Bhattarai BR, Kafle B, Lee KH, Cho H..  (2008)  Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity..  Bioorg Med Chem,  16  (18): (8643-8652).  [PMID:18722777]
10. Yu WM, Guvench O, Mackerell AD, Qu CK..  (2008)  Identification of small molecular weight inhibitors of Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) via in silico database screening combined with experimental assay..  J Med Chem,  51  (23): (7396-7404).  [PMID:19007293]
11. Vidović D, Schürer SC..  (2009)  Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design..  J Med Chem,  52  (21): (6649-6659).  [PMID:19810703]
12. Zhang X, He Y, Liu S, Yu Z, Jiang ZX, Yang Z, Dong Y, Nabinger SC, Wu L, Gunawan AM, Wang L, Chan RJ, Zhang ZY..  (2010)  Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)..  J Med Chem,  53  (6): (2482-2493).  [PMID:20170098]
13. Bu Y, Shi T, Meng M, Kong G, Tian Y, Chen Q, Yao X, Feng G, Chen H, Lu Z..  (2011)  A novel screening model for the molecular drug for diabetes and obesity based on tyrosine phosphatase Shp2..  Bioorg Med Chem Lett,  21  (2): (874-878).  [PMID:21169016]
14. Vang T, Xie Y, Liu WH, Vidović D, Liu Y, Wu S, Smith DH, Rinderspacher A, Chung C, Gong G, Mustelin T, Landry DW, Rickert RC, Schürer SC, Deng SX, Tautz L..  (2011)  Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids..  J Med Chem,  54  (2): (562-571).  [PMID:21190368]
15. Yang JW, He XP, Li C, Gao LX, Sheng L, Xie J, Shi XX, Tang Y, Li J, Chen GR..  (2011)  A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides..  Bioorg Med Chem Lett,  21  (4): (1092-1096).  [PMID:21251827]
16. Yu ZH, Chen L, Wu L, Liu S, Wang L, Zhang ZY..  (2011)  Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening..  Bioorg Med Chem Lett,  21  (14): (4238-4242).  [PMID:21669525]
17. Bhattarai BR, Kafle B, Hwang JS, Ham SW, Lee KH, Park H, Han IO, Cho H..  (2010)  Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-γ activators..  Bioorg Med Chem Lett,  20  (22): (6758-6763).  [PMID:20850970]
18. He Y, Xu J, Yu ZH, Gunawan AM, Wu L, Wang L, Zhang ZY..  (2013)  Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold..  J Med Chem,  56  (3): (832-842).  [PMID:23305444]
19. Liu W, Yu B, Xu G, Xu WR, Loh ML, Tang LD, Qu CK..  (2013)  Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11)..  J Med Chem,  56  (18): (7212-7221).  [PMID:23957426]
20. Chen YT, Tang CL, Ma WP, Gao LX, Wei Y, Zhang W, Li JY, Li J, Nan FJ..  (2013)  Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy..  Eur J Med Chem,  69  (399-412).  [PMID:24090912]
21. Zhi Y, Gao LX, Jin Y, Tang CL, Li JY, Li J, Long YQ..  (2014)  4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B..  Bioorg Med Chem,  22  (14): (3670-3683).  [PMID:24906513]
22. Hou S, Yi YW, Kang HJ, Zhang L, Kim HJ, Kong Y, Liu Y, Wang K, Kong HS, Grindrod S, Bae I, Brown ML..  (2014)  Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6..  J Med Chem,  57  (15): (6342-6353).  [PMID:24978112]
23. Zeng LF, Zhang RY, Yu ZH, Li S, Wu L, Gunawan AM, Lane BS, Mali RS, Li X, Chan RJ, Kapur R, Wells CD, Zhang ZY..  (2014)  Therapeutic potential of targeting the oncogenic SHP2 phosphatase..  J Med Chem,  57  (15): (6594-6609).  [PMID:25003231]
24. Sasaki T, Li W, Higai K, Koike K..  (2015)  Canthinone alkaloids are novel protein tyrosine phosphatase 1B inhibitors..  Bioorg Med Chem Lett,  25  (9): (1979-1981).  [PMID:25819098]
25. He Y, Guo X, Yu ZH, Wu L, Gunawan AM, Zhang Y, Dixon JE, Zhang ZY..  (2015)  A potent and selective inhibitor for the UBLCP1 proteasome phosphatase..  Bioorg Med Chem,  23  (12): (2798-2809).  [PMID:25907364]
26. Jiang B, Pei D..  (2015)  A Selective, Cell-Permeable Nonphosphorylated Bicyclic Peptidyl Inhibitor against Peptidyl-Prolyl Isomerase Pin1..  J Med Chem,  58  (15): (6306-6312).  [PMID:26196061]
27. He R, Bai Y, Yu ZH, Wu L, Gunawan AM, Zhang ZY..  (2014)  Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis..  Medchemcomm,  (10): (1496-1499).  [PMID:25505942]
28. Liu P, Du Y, Song L, Shen J, Li Q..  (2015)  Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic..  Bioorg Med Chem,  23  (21): (7079-7088).  [PMID:26481657]
29. Liu P, Du Y, Song L, Shen J, Li Q..  (2016)  Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity..  Eur J Med Chem,  118  (27-33).  [PMID:27123900]
30. Gubiani JR, Wijeratne EM, Shi T, Araujo AR, Arnold AE, Chapman E, Gunatilaka AA..  (2017)  An epigenetic modifier induces production of (10'S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla..  Bioorg Med Chem,  25  (6): (1860-1866).  [PMID:28202316]
31. Dong S, Lei Y, Jia S, Gao L, Li J, Zhu T, Liu S, Hu W..  (2017)  Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction..  Bioorg Med Chem Lett,  27  (4): (1105-1108).  [PMID:28111140]
32. Xie J, Si X, Gu S, Wang M, Shen J, Li H, Shen J, Li D, Fang Y, Liu C, Zhu J..  (2017)  Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment..  J Med Chem,  60  (24): (10205-10219).  [PMID:29155585]
33. Du Y, Zhang Y, Ling H, Li Q, Shen J..  (2018)  Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site..  Eur J Med Chem,  144  (692-700).  [PMID:29289892]
34. Wang WL, Chen XY, Gao Y, Gao LX, Sheng L, Zhu J, Xu L, Ding ZZ, Zhang C, Li JY, Li J, Zhou YB..  (2017)  Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors..  Bioorg Med Chem Lett,  27  (23): (5154-5157).  [PMID:29100798]
35. Zhang J, Sasaki T, Li W, Nagata K, Higai K, Feng F, Wang J, Cheng M, Koike K..  (2018)  Identification of caffeoylquinic acid derivatives as natural protein tyrosine phosphatase 1B inhibitors from Artemisia princeps..  Bioorg Med Chem Lett,  28  (7): (1194-1197).  [PMID:29525218]
36. Kyriakou E, Schmidt S, Dodd GT, Pfuhlmann K, Simonds SE, Lenhart D, Geerlof A, Schriever SC, De Angelis M, Schramm KW, Plettenburg O, Cowley MA, Tiganis T, Tschöp MH, Pfluger PT, Sattler M, Messias AC..  (2018)  Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus..  J Med Chem,  61  (24): (11144-11157).  [PMID:30525586]
37. Li X, Xu Q, Li C, Luo J, Li X, Wang L, Jiang B, Shi D..  (2019)  Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors..  Eur J Med Chem,  166  (178-185).  [PMID:30711829]
38. Jiao WH, Li J, Wang D, Zhang MM, Liu LY, Sun F, Li JY, Capon RJ, Lin HW..  (2019)  Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea..  J Nat Prod,  82  (9): (2586-2593).  [PMID:31532203]
39. Wu X, Xu G, Li X, Xu W, Li Q, Liu W, Kirby KA, Loh ML, Li J, Sarafianos SG, Qu CK..  (2019)  Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2..  J Med Chem,  62  (3): (1125-1137).  [PMID:30457860]
40. Yuan X,Bu H,Zhou J,Yang CY,Zhang H.  (2020)  Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application..  J Med Chem,  63  (20.0): (11368-11396).  [PMID:32460492]
41. He R,Wang J,Yu ZH,Zhang RY,Liu S,Wu L,Zhang ZY.  (2016)  Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism..  J Med Chem,  59  (19.0): (9094-9106).  [PMID:27676368]
42. Shen, S H SH, Bastien, L L, Posner, B I BI and Chrétien, P P..  (1991)  A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases..  Nature,    (22):   [PMID:1652101]
43. Yi, T L TL, Cleveland, J L JL and Ihle, J N JN..  (1992)  Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13..  Molecular and cellular biology,      [PMID:1732748]
44. Plutzky, J J, Neel, B G BG and Rosenberg, R D RD..  (1992)  Isolation of a src homology 2-containing tyrosine phosphatase..  Proceedings of the National Academy of Sciences of the United States of America,    (1):   [PMID:1736296]
45. Banville, D D, Stocco, R R and Shen, S H SH..  (1995)  Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts..  Genomics,    (1):   [PMID:7665165]
46. Li, R Y RY, Gaits, F F, Ragab, A A, Ragab-Thomas, J M JM and Chap, H H..  (1995)  Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein..  The EMBO journal,    (1):   [PMID:7781604]
47. Ansari-Lari, M A MA, Shen, Y Y, Muzny, D M DM, Lee, W W and Gibbs, R A RA..  (1997)  Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination..  Genome research,      [PMID:9074930]
48. Cella, M M and 6 more authors..  (1997)  A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing..  The Journal of experimental medicine,    (19):   [PMID:9151699]
49. Cosman, D D and 6 more authors..  (1997)  A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules..  Immunity,      [PMID:9285411]
50. Veillette, A A, Thibaudeau, E E and Latour, S S..  (1998)  High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages..  The Journal of biological chemistry,    (28):   [PMID:9712903]
51. Yang, J J and 5 more authors..  (1998)  Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1..  The Journal of biological chemistry,    (23):   [PMID:9774441]
52. Fanger, N A NA and 5 more authors..  (1998)  The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes..  European journal of immunology,      [PMID:9842885]
53. Jin, Y J YJ, Yu, C L CL and Burakoff, S J SJ..  (1999)  Human 70-kDa SHP-1L differs from 68-kDa SHP-1 in its C-terminal structure and catalytic activity..  The Journal of biological chemistry,    (1):   [PMID:10497187]
54. Yoshida, K K, Kharbanda, S S and Kufe, D D..  (1999)  Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage..  The Journal of biological chemistry,    (3):   [PMID:10574931]
55. Xu , M J MJ, Zhao, R R and Zhao, Z J ZJ..  (2001)  Molecular cloning and characterization of SPAP1, an inhibitory receptor..  Biochemical and biophysical research communications,    (26):   [PMID:11162587]
56. Keilhack, H H and 12 more authors..  (2001)  Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1..  The Journal of cell biology,    (22):   [PMID:11266449]
57. Lewis, J J and 7 more authors..  (2001)  Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family..  Clinical immunology (Orlando, Fla.),      [PMID:11414741]
58. Yang, Jian J and 6 more authors..  (2003)  Crystal structure of human protein-tyrosine phosphatase SHP-1..  The Journal of biological chemistry,    (21):   [PMID:12482860]
59. Ehrhardt, Gotz R A GR and 5 more authors..  (2003)  The inhibitory potential of Fc receptor homolog 4 on memory B cells..  Proceedings of the National Academy of Sciences of the United States of America,    (11):   [PMID:14597715]
60. Andersen, Jens S JS and 5 more authors..  (2003)  Proteomic characterization of the human centrosome by protein correlation profiling..  Nature,    (4):   [PMID:14654843]
61. Sui, Lili L and 8 more authors..  (2004)  IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes..  Biochemical and biophysical research communications,    (2):   [PMID:15184070]
62. Rönnstrand, L L..  (2004)  Signal transduction via the stem cell factor receptor/c-Kit..  Cellular and molecular life sciences : CMLS,      [PMID:15526160]
63. Roskoski, Robert R..  (2005)  Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor..  Biochemical and biophysical research communications,    (11):   [PMID:16129412]
64. Kim-Schulze, Seunghee S and 7 more authors..  (2006)  Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells..  Journal of immunology (Baltimore, Md. : 1950),    (1):   [PMID:16493035]
65. Scherer, Steven E SE and 216 more authors..  (2006)  The finished DNA sequence of human chromosome 12..  Nature,    (16):   [PMID:16541075]
66. Hoffmann, Sabrina C SC and 7 more authors..  (2007)  Identification of CLEC12B, an inhibitory receptor on myeloid cells..  The Journal of biological chemistry,    (3):   [PMID:17562706]
67. Yu, Ming-Can MC and 14 more authors..  (2008)  An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells..  Nature immunology,      [PMID:18604210]
68. Sheng, M H-C and Lau, K-H W..  (2009)  Role of protein-tyrosine phosphatases in regulation of osteoclastic activity..  Cellular and molecular life sciences : CMLS,      [PMID:19189046]
69. Sephton, C F CF and 5 more authors..  (2009)  The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1..  Cellular signalling,      [PMID:19591923]
70. Mayya, Viveka V and 7 more authors..  (2009)  Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions..  Science signaling,    (18):   [PMID:19690332]
71. Kochi, Yuta Y and 6 more authors..  (2009)  FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling..  Journal of immunology (Baltimore, Md. : 1950),    (1):   [PMID:19843936]
72. Kulemzin, Sergey V SV and 18 more authors..  (2011)  FCRL6 receptor: expression and associated proteins..  Immunology letters,    (30):   [PMID:20933011]
73. Hsu, Jung-Mao JM and 14 more authors..  (2011)  Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation..  Nature cell biology,      [PMID:21258366]
74. Fiset, Annie A and 8 more authors..  (2011)  Compartmentalized CDK2 is connected with SHP-1 and β-catenin and regulates insulin internalization..  Cellular signalling,      [PMID:21262353]
75. Wang, Wei W and 7 more authors..  (2011)  Crystal structure of human protein tyrosine phosphatase SHP-1 in the open conformation..  Journal of cellular biochemistry,      [PMID:21465528]
76. Mazharian, Alexandra A and 14 more authors..  (2012)  Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function..  Science signaling,    (30):   [PMID:23112346]

Solution Calculators