| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| R342426-10μg | 10μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $178.90 |
a lipid mediator
| Synonyms | C18179 | CS-0082932 | HY-121636 | SCHEMBL3407534 | IKFAUGXNBOBQDM-XFMPMKITSA-N | Q60998704 | CHEBI:81565 | RvD2 | Resolvin D2-[d5] | AKOS027307761 | DTXSID801347465 | (4Z,7R,8E,10Z,12E,14E,16R,17S,19Z)-7,16,17-trihydroxydocosa-4,8,10,12,14,19-hexaenoic ac |
|---|---|
| Specifications & Purity | ≥95%, 100μg/mL in ethanol |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation. It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM. Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance. |
| IUPAC Name | (4Z,7S,8E,10Z,12E,14E,16R,17S,19Z)-7,16,17-trihydroxydocosa-4,8,10,12,14,19-hexaenoic acid |
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| INCHI | InChI=1S/C22H32O5/c1-2-3-9-16-20(24)21(25)17-12-7-5-4-6-10-14-19(23)15-11-8-13-18-22(26)27/h3-12,14,17,19-21,23-25H,2,13,15-16,18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,11-8-,14-10+,17-12+/t19-,20+,21-/m1/s1 |
| InChi Key | IKFAUGXNBOBQDM-XFMPMKITSA-N |
| Canonical SMILES | CCC=CCC(C(C=CC=CC=CC=CC(CC=CCCC(=O)O)O)O)O |
| Isomeric SMILES | CC/C=C\C[C@@H]([C@@H](/C=C/C=C/C=C\C=C\[C@H](C/C=C\CCC(=O)O)O)O)O |
| PubChem CID | 11383310 |
| UN Number | 1170 |
| Packing Group | II |
| Molecular Weight | 376.5 |
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| Solubility | Soluble in PBS pH 7.2 (~0.05 mg/ml), DMSO (~50 mg/ml), and DMF (~50 mg/ml). |
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| Refractive Index | n20D1.55 (Predicted) |
| Boil Point(°C) | 78° C |
| Class | 3 |
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