RF9 hydrochloride - 10mM in DMSO, high purity , CAS No.R661629(DMSO)

  • 10mM in DMSO
Item Number
R661629
Grouped product items
SKUSizeAvailabilityPrice Qty
R661629-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$260.90

Basic Description

Specifications & Purity10mM in DMSO
Storage TempDesiccated,Store at -80°C
Shipped InIce chest + Ice pads
Product Description

RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with K i values of 58 and 75 nM for hNPFF1R and hNPFF2R , respectively.

IC50& Target:hNPFF1R 58 nM (Ki) hNPFF2R 75 nM (Ki)

In Vitro:RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo:RF9 (0.1mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance. RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoke

Biological Activity:RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with K i values of 58 and 75 nM for hNPFF1R and hNPFF2R , respectively .

Names and Identifiers

Canonical SMILES NC(C(CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC(C23C[C@H](C4)CC(C[C@@H]4C3)C2)=O)=O)=O.Cl
Molecular Weight 519.08

Certificates

C of A & Other Certificates

Related Documents

Solution Calculators