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Riluzole (PK 26124) - ≥99%, high purity , CAS No.850608-87-6

≥99%

CAS#: 850608-87-6
Formula: C₈H₅F₃N₂OS.HCl
Molecular Weight: 270.66
PubChem CID: 6419992

Item Number

R275242

Grouped product items
SKU	Size	Availability	Price
R275242-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$29.90
R275242-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$87.90
R275242-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$339.90

Neuroprotective agent. Modulates glutamate transmission.

Basic Description

Synonyms	2-Amino-6-trifluoromethoxybenzothiazolehydrochloride
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Biological description: A neuroprotective agent with anticonvulsant, sedative, anti anxiety, anti ischemic, and anesthetic effects. Inhibiting glutamate release, increasing glutamate absorption, blocking voltage dependent Na+channels, antagonizing NMDA re
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Discover Target: EHMT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RAB9A Tbio Ras-related protein Rab-9A 0 Activities

Discover Target: RAB9A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NPC1 Tchem NPC intracellular cholesterol transporter 1 0 Activities

Discover Target: NPC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	6-(trifluoromethoxy)-1,3-benzothiazol-2-amine;hydrochloride
INCHI	InChI=1S/C8H5F3N2OS.ClH/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5;/h1-3H,(H2,12,13);1H
InChi Key	QEAOELIJQRYJJS-UHFFFAOYSA-N
Canonical SMILES	C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N.Cl
Isomeric SMILES	C1=CC2=C(C=C1OC(F)(F)F)SC(=N2)N.Cl
PubChem CID	6419992
Molecular Weight	270.66

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
A2404591	Certificate of Analysis	Dec 15, 2023	R275242
A2404592	Certificate of Analysis	Dec 15, 2023	R275242
A2404593	Certificate of Analysis	Dec 15, 2023	R275242
A2404594	Certificate of Analysis	Dec 15, 2023	R275242
A2404595	Certificate of Analysis	Dec 15, 2023	R275242
A2404596	Certificate of Analysis	Dec 15, 2023	R275242

Solubility

Soluble in DMSO to 100 mM and in water to 10 mM

Sensitivity

Moisture sensitive.

References

1. Wei XP et al.. (2022) A novel reticular node in the brainstem synchronizes neonatal mouse crying with breathing.. Neuron, 110 (4): (644-657.e6). [PMID:34998469]
2. Mishra P & Narayanan R. (2022) Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells.. iScience, 25 (3): (103922). [PMID:35252816]
3. Ramakrishnan L et al.. (2013) Riluzole attenuates the effects of chemoconvulsants acting on glutamatergic and GABAergic neurotransmission in the planarian Dugesia tigrina.. Eur J Pharmacol, 718 (1-3): (493-501). [PMID:23872399]

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