RITA|213261-59-7|NSC 652287|RITA (NSC 652287)|p53 Activator III, RITA|5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol|SOS BISMETHANOL|(5,5'-(furan-2,5-diyl)bis(thiophene-5,2-diyl))dimethanol|[5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]metha
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
p53 Activator III, RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis. Renal carcinoma research has demonstrated that RITA in
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53. A trycyclic thiophene derivative that binds MDM2, activates p53 and induces apoptosis.
Soluble in DMSO (58 mg/ml at 25 °C), ethanol (8 mg/ml at 25 °C), DMF (30 mg/ml), 1:1 solution of dimethyl formamide: PBS (pH 7.2) (0.5 mg/ml, dissolve RITA first in dimethyl formamide and then dilute with PBS), and water (<1 mg/ml at 25 °C).
F1509074