RO 19-4603 , CAS No.99632-94-7, Allosteric modulator of GABA A receptor α1 subunit;Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Allosteric modulator of GABA A receptor α5 subunit

Item Number

R350044

• Synonyms: 99632-94-7|Ro 19-4603|RO19-4603|tert-butyl 5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylate|Tocris-1995|Ro-19-4603|5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLE
• Specifications & Purity: Moligand™
• Storage Temp: Room temperature
• Shipped In: Normal
• Grade: Moligand™
• Action Type: ALLOSTERIC MODULATOR
• Mechanism of action: Allosteric modulator of GABA A receptor α1 subunit;Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Allosteric modulator of GABA A receptor α5 subunit

Product Description

RO 19-4603 is a benzodiazepine inverse agonist. Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABA|A|receptors (K|i|values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively).