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RO-3 - ≥98%(HPLC), high purity , CAS No.1026582-88-6, Antagonist of P2X3

Moligand™
≥98%(HPLC)

CAS#: 1026582-88-6
Formula: C₁₆H₂₂N₄O₂
Molecular Weight: 302.37
PubChem CID: 11289644

Item Number

R288608

Grouped product items
SKU	Size	Availability	Price
R288608-5mg	5mg	In stock	$296.90
R288608-10mg	10mg	In stock	$444.90
R288608-25mg	25mg	In stock	$800.90
R288608-50mg	50mg	In stock	$1,137.90
R288608-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,048.90

Selective P2X3and P2X2/3antagonist

View related series

P2X3 Antagonist

Basic Description

Synonyms	5-[[4,5-Dimethoxy-2-(methylethyl)phenyl]methyl]-2,4-pyrimidinediamine；5-(2-isopropyl-4,5-dimethoxybenzyl)pyrimidine-2,4-diamine
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective homotypic P2X3 and heterotypic P2X2/3 receptor antagonist (pIC50 7.0 and 5.9, respectively), inactive at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in an animal model of pain
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of P2X3
Product Description	RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RX3 Tclin P2X purinoceptor 3 1 Activities

Discover Target: P2RX3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RX2 Tchem P2X purinoceptor 2 0 Activities

Discover Target: P2RX2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-[(4,5-dimethoxy-2-propan-2-ylphenyl)methyl]pyrimidine-2,4-diamine
INCHI	InChI=1S/C16H22N4O2/c1-9(2)12-7-14(22-4)13(21-3)6-10(12)5-11-8-19-16(18)20-15(11)17/h6-9H,5H2,1-4H3,(H4,17,18,19,20)
InChi Key	PYNPWUIBJMVRIG-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1=CC(=C(C=C1CC2=CN=C(N=C2N)N)OC)OC
Isomeric SMILES	CC(C)C1=CC(=C(C=C1CC2=CN=C(N=C2N)N)OC)OC
PubChem CID	11289644
Molecular Weight	302.37

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
C2214263	Certificate of Analysis	Feb 16, 2022	R288608
C2214264	Certificate of Analysis	Feb 16, 2022	R288608
C2214271	Certificate of Analysis	Feb 16, 2022	R288608
C2214288	Certificate of Analysis	Feb 16, 2022	R288608
C2214289	Certificate of Analysis	Feb 16, 2022	R288608

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