Ro 31-9790 is a synthetic metalloproteinase ( MMP ) inhibitor.
In Vitro
Ro 31-9790 inhibits L-selectin shedding from mouse and human lymphocytes, Jurkat T cells, and human monocytes with an IC 50 of 0.3-0.4 μM on these cell types. The IC 50 values obtained for Ro 31-9790 are 4.82 ± 0.75 μM, 1.16 ± 0.27 μM, 0.70 ± 0.06 μM, 4.47± 1.27 μM and 0.38 ± 0.05 μM for mouse lymphocyte L-selectin shedding, Jurkat L-selectin shedding, human lymphocyte L-selectin shedding, human monocyte L-selectin shedding and human monocyte TNF-α shedding. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:MMP
Names and Identifiers
Canonical SMILES
O=C(N[C@H](C(NC)=O)C(C)(C)C)[C@H](CC(C)C)CC(NO)=O
Molecular Weight
315.41
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
Solubility
DMSO : 50 mg/mL (158.52 mM; ultrasonic and warming and heat to 70°C)
