Skip to the beginning of the images gallery

Ro 64-5229 - ≥99%(HPLC), high purity , CAS No.246852-46-0, Allosteric modulator of mGlu 2 receptor

Moligand™
≥99%(HPLC)

CAS#: 246852-46-0
Formula: C₁₇H₁₉Cl₂N₃O
Molecular Weight: 352.26
PubChem CID: 10428048

Item Number

R288543

Grouped product items
SKU	Size	Availability	Price	Qty
R288543-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$211.90
R288543-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$862.90

Selective, non-competitive mGlu2antagonist

View related series

mGlu2 receptor Allosteric modulator

Basic Description

Synonyms	(Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole
Specifications & Purity	Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms	Selective, non-competitive mGlu2antagonist. Inhibits GTPγ35S binding to mGlu2-containing membranes (IC50= 0.11μM).
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of mGlu 2 receptor

Associated Targets

GRM1 Tchem Metabotropic glutamate receptor 1 0 Activities

Discover Target: GRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA3 Tclin Glutamate receptor 3 0 Activities

Discover Target: GRIA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIK2 Tclin Glutamate receptor ionotropic, kainate 2 0 Activities

Discover Target: GRIK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM2 Tchem Metabotropic glutamate receptor 2 1 Activities

Discover Target: GRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM4 Tchem Metabotropic glutamate receptor 4 0 Activities

Discover Target: GRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM5 Tchem Metabotropic glutamate receptor 5 0 Activities

Discover Target: GRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM3 Tchem Metabotropic glutamate receptor 3 0 Activities

Discover Target: GRM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN2C Tclin Glutamate receptor ionotropic, NMDA 2C 0 Activities

Discover Target: GRIN2C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-[(Z)-2-cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1,2,4-triazole
INCHI	InChI=1S/C17H19Cl2N3O/c18-14-8-5-9-15(19)17(14)16(10-22-12-20-11-21-22)23-13-6-3-1-2-4-7-13/h5,8-13H,1-4,6-7H2/b16-10-
InChi Key	STCVFKBRXOEQRF-YBEGLDIGSA-N
Canonical SMILES	C1CCCC(CC1)OC(=CN2C=NC=N2)C3=C(C=CC=C3Cl)Cl
Isomeric SMILES	C1CCCC(CC1)O/C(=C\N2C=NC=N2)/C3=C(C=CC=C3Cl)Cl
PubChem CID	10428048
Molecular Weight	352.26

PubChem CID

ChEMBL Ligand

CAS Registry No.

GPCRdb Ligand

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.