ROCK inhibitor 3 , CAS No.R613264, Inhibitor of Rho associated coiled-coil containing protein kinase 1;Inhibitor of Rho associated coiled-coil containing protein kinase 2

Item Number

R613264

Grouped product items
SKU	Size	Availability	Price	Qty
R613264-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
R613264-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Synonyms

Chiesi Rock inhibitor;example 3 [WO2010032875A2]

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of Rho associated coiled-coil containing protein kinase 1;Inhibitor of Rho associated coiled-coil containing protein kinase 2

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-fluoro-2-methoxy-6-{[(1r,4r)-4-aminocyclohexyl]amino}pyridine-3-carboxamide
INCHI	InChI=1S/C13H19FN4O2/c1-20-13-9(11(16)19)6-10(14)12(18-13)17-8-4-2-7(15)3-5-8/h6-8H,2-5,15H2,1H3,(H2,16,19)(H,17,18)/t7-,8-
InChi Key	IMZIJLMIOSQRGE-ZKCHVHJHSA-N
Canonical SMILES	COc1nc(N[C@@H]2CC[C@H](CC2)N)c(cc1C(=O)N)F
Isomeric SMILES	COC1=NC(=C(C=C1C(=O)N)F)NC2CCC(CC2)N
PubChem CID	46182713

References

1. Cantoni S, Cavalli S, Pastore F, Accetta A, Pala D, Vaccaro F, Cesari N, De Logu F, Nassini R, Villetti G et al.. (2019) Pharmacological characterization of a highly selective Rho kinase (ROCK) inhibitor and its therapeutic effects in experimental pulmonary hypertension.. Eur J Pharmacol, 850 (3): (126-134). [PMID:30753868]
2. Dayal N, Mikek CG, Hernandez D, Naclerio GA, Yin Chu EF, Carter-Cooper BA, Lapidus RG, Sintim HO. (2019) Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors.. Eur J Med Chem, 180 (3): (449-456). [PMID:31330446]

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Basic Description