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Ropivacaine hydrochloride - 98%, high purity , Sodium channel alpha subunit blocker, CAS No.98717-15-8, Sodium channel alpha subunit blocker

≥98%

CAS#: 98717-15-8
Formula: C₁₇H₂₇ClN₂O
Molecular Weight: 310.86
PubChem CID: 175804
PubChem SID: 488188493

Item Number

R413090

Grouped product items
SKU	Size	Availability	Price	Qty
R413090-10mg	10mg	In stock	$48.90
R413090-50mg	50mg	In stock	$77.90

Sodium Channel Inhibitors

Basic Description

Synonyms	Ropivacaine hydrochloride\|ROPIVACAINE HCl\|98717-15-8\|Ropivacaine monohydrochloride\|Naropin\|Ropivacaine (hydrochloride)\|DTXSID2048379\|35504LBE2T\|MFCD02102164\|(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide;hydrochloride\|2-Piperidinecarboxamide
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Ropivacaine HCl (LEA-103) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	BLOCKER
Mechanism of action	Sodium channel alpha subunit blocker
Product Description	Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is widely used for neuropathic pain management in vivo.

Associated Targets

ERG Tbio Transcriptional regulator ERG 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CBX1 Tbio Chromobox protein homolog 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488188493
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488188493
IUPAC Name	(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide;hydrochloride
INCHI	InChI=1S/C17H26N2O.ClH/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H/t15-;/m0./s1
InChi Key	NDNSIBYYUOEUSV-RSAXXLAASA-N
Canonical SMILES	CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
Isomeric SMILES	CCCN1CCCC[C@H]1C(=O)NC2=C(C=CC=C2C)C.Cl
PubChem CID	175804
Molecular Weight	310.86

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
D2326353	Certificate of Analysis	May 06, 2023	R413090
D2326360	Certificate of Analysis	May 06, 2023	R413090
D2326362	Certificate of Analysis	May 06, 2023	R413090
D2326369	Certificate of Analysis	May 06, 2023	R413090

Solubility

Solubility (25°C) In vitro DMSO: 62 mg/mL (199.44 mM); Ethanol: 62 mg/mL (199.44 mM); Water: 46 mg/mL (147.97 mM);

Sensitivity

Moisture sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H412:Harmful to aquatic life with long lasting effects H302:Harmful if swallowed H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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