Rose bengal - Biological stain, high purity , CAS No.632-69-9

Item Number
R104991
Grouped product items
SKUSizeAvailabilityPrice Qty
R104991-10g
10g
In stock
$55.90
R104991-50g
50g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$199.90
R104991-250g
250g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$789.90

Basic Description

Synonyms632-69-9 | Xantryl | Food Red No. 105, sodium salt | PV 10 | Rose Bengal (sodium salt)(1:2) | Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-, disodium salt | R105 sodium | (3-Oxo-6-oxido-2,4,5,7-tetraiodo-3h-
Specifications & PurityBiological stain
Storage TempProtected from light,Desiccated
Shipped InNormal
GradeBiological stain
Product Description

Product Description:
Rose Bengal is a stain used in the eye drops to identify the eye damage. It finds application in the preparation of foraminifera for microscopic analysis, photosensitizing reactions and as a dye. In synthetic chemistry, it is utilized to convert triplet oxygen to singlet oxygen, which is used in [2+2] cycloadditions with alkenes. Its derivatives have important medical functions and used for the treatment of cancer. It acts as an alternative to phloxine B in Kreyberg's stain for keratin and mucus. As a fluorescent probe, it is used for the determination of NAD binding sites of alcohol dehydrogenase. Product Application:
Rose Bengal is a red or rose color dye and is anionic in nature. It is a 4,5,6,7-tetrachloro 2′,4′,5′,7′-tetraiodo derivative of fluorescein. It is widely used to detect damage to the ocular surface epithelium in ocular surface diseases such as dry eye and herpetic keratitis. Rose Bengal has mild antiviral potency.Rose Bengal is used to stain dead and degenerating cells and mucus.

Names and Identifiers

Pubchem Sid488184325
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488184325
IUPAC Name disodium;4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate
INCHI InChI=1S/C20H4Cl4I4O5.2Na/c21-9-7-8(10(22)12(24)11(9)23)20(33-19(7)31)3-1-5(25)15(29)13(27)17(3)32-18-4(20)2-6(26)16(30)14(18)28;;/h1-2,29-30H;;/q;2*+1/p-2
InChi Key KCQREHTWEUECQT-UHFFFAOYSA-L
Canonical SMILES C1=C2C(=C(C(=C1I)[O-])I)OC3=C(C(=C(C=C3C24C5=C(C(=C(C(=C5Cl)Cl)Cl)Cl)C(=O)O4)I)[O-])I.[Na+].[Na+]
Isomeric SMILES C1=C2C(=C(C(=C1I)[O-])I)OC3=C(C(=C(C=C3C24C5=C(C(=C(C(=C5Cl)Cl)Cl)Cl)C(=O)O4)I)[O-])I.[Na+].[Na+]
WGK Germany 3
RTECS LM5920000
PubChem CID 69438
Molecular Weight 1017.64
Beilstein 3645857

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
A2408032Certificate of AnalysisOct 28, 2022 R104991
B2317267Certificate of AnalysisOct 28, 2022 R104991
B2317301Certificate of AnalysisOct 28, 2022 R104991
K2224635Certificate of AnalysisOct 28, 2022 R104991
K2224638Certificate of AnalysisOct 28, 2022 R104991
K2224658Certificate of AnalysisOct 28, 2022 R104991

Chemical and Physical Properties

SensitivityLight sensitive.
Melt Point(°C)>300℃

Safety and Hazards(GHS)

WGK Germany 3
RTECS LM5920000

Related Documents

Citations of This Product

1. Abdul Ghaffar, Muhammad Hassan, Oleksiy V. Penkov, Cafer T. Yavuz, Kemal Celebi.  (2023)  Tunable Molecular Sieving by Hierarchically Assembled Porous Organic Cage Membranes with Solvent-Responsive Switchable Pores.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,  57  (48): (20380–20391).  [PMID:37965815]
2. Jin-Bo Li, Cheng-Ye Zhu, Bian-Bian Guo, Chang Liu, Jia-Hui Xin, Chao Zhang, Jian Wu, Lin Zhang, Hao-Cheng Yang, Zhi-Kang Xu.  (2024)  Ultrahigh-permeance polyamide thin-film composite membranes enabled by interfacial polymerization on a macro-porous substrate toward organic solvent nanofiltration.  JOURNAL OF MEMBRANE SCIENCE,  693  (122342).  [PMID:]
3. Wenjing Geng, Zechen Zhang, Qi Guo, Yuchen Liu, Xinxin Ye, Hui Zhang, Chen Fu, Fengguang Liu, Yujun Zhu, Cheng Chen.  (2023)  Tailoring graphene oxide nanofiltration membrane with adjustable nanochannels for enhanced molecule separation.  CHEMICAL ENGINEERING JOURNAL,  478  (27): (147327).  [PMID:9732876]
4. Liying Pan, Shihua Wang, Mintao Xie, Manshan Liang, Lichao Yu, Bing Du, Xiaoxia Ye, Yanshu Luo, Yun-Yun Quan, Zu-Sheng Huang.  (2023)  Biotin receptor and mitochondria dual targeted AIE photosensitizer for fluorescence imaging guided photodynamic anticancer therapy.  MATERIALS & DESIGN,  235  (26): (112441).  [PMID:16510448]
5. Zhe Wang, Yansha Zeng, Yue Shen, Qiyin Tan, Jiahao Sun, Jiaheng Teng, Hongjun Lin.  (2024)  Innovative integration of porous materials and membranes: Achieving optimized pore orientation for enhanced performance.  JOURNAL OF MEMBRANE SCIENCE,  689  (1): (122158).  [PMID:31434731]
6. Yanling Xiao, Yuying Yuan, Manshan Liang, Jiahao Ni, Lichao Yu, Zu-Sheng Huang, Bing Du, Yun-Yun Quan.  (2023)  Efficient type Ⅰ and type Ⅱ ROS generated aggregation-induced emission photosensitizer for mitochondria targeted photodynamic therapy.  DYES AND PIGMENTS,  220  (8): (111765).  [PMID:19920177]
7. Dong Yangbo, Feng Danyang, Li Wei, Zhang Rui, Dou Shuzhen, Wang Luoqi, Yang Yan, Wang Li, Yang Yang, Wei Feng, Qiao Zhen-An.  (2023)  Interfacial co-assembly strategy towards gradient mesoporous hollow sheet for molecule filtration.  NPG Asia Materials,  15  (1): (1-8).  [PMID:10961885]
8. Heguo Han, Chi Zhang, Huiting Yu, Zheng Liu, Jing Guo, Qifeng Zhang, Yuxuan Sun, Shenghai Li, Suobo Zhang.  (2023)  A novel organic solvent nanofiltration membrane prepared via green mild and simple crosslinking process.  JOURNAL OF MEMBRANE SCIENCE,  688  (122151).  [PMID:19185582]
9. Qing Fang, Qin Liu, Zongli Xie, Matthew R. Hill, Kaisong Zhang.  (2024)  Ultra-thin PTMSP nanocomposite membranes incorporated with functionalized MoS2 nanosheets for pharmaceutical concentration and solvent recovery.  SEPARATION AND PURIFICATION TECHNOLOGY,  330  (125296).  [PMID:16479015]
10. Jiayi Wu, Qin Liu, Yan Wang.  (2024)  Robust thin film composite membrane with Cu2+ integrally-crosslinking for organic solvent nanofiltration.  SEPARATION AND PURIFICATION TECHNOLOGY,  330  (29): (125229).  [PMID:12702766]
11. Yan-Zi Wang, Xin-Li An, Xiao-Ting Fan, Qiang Pu, Hu Li, Wen-Zhen Liu, Zhuo Chen, Jian-Qiang Su.  (2024)  Visible light-activated photosensitizer inhibits the plasmid-mediated horizontal gene transfer of antibiotic resistance genes.  JOURNAL OF HAZARDOUS MATERIALS,  461  (132564).  [PMID:37734313]
12. Kaili Huo, Jin Wang, Jianguo Zhang, Yuqiang Zhao, Shanjun Liu, Mengmeng Dou, Xiaoyue Wang, Qingyun Zhang, Chao Han, Wubin Wang, Chaoxu Zhou, Yahui Xu.  (2023)  Fabrication of a novel composite nanofiltration membrane with effective treating dye wastewater via integration of phase inversion and interfacial polymerization.  Journal of Environmental Chemical Engineering,  11  (111013).  [PMID:26779609]
13. Hongying Li, Fei Shi, Shuhui Chen, Yifan Li.  (2024)  Organic-inorganic hybrid two-dimensional membranes with enhanced solvent flux and stability.  SEPARATION AND PURIFICATION TECHNOLOGY,  328  (12): (124917).  [PMID:16517606]
14. Chao Han, Huan Liu, Yida Wang, Fuxin Zheng, Gang Han, Yan Wang.  (2023)  Thermal crosslinking and cyclodehydration assisted fabrication of chemically robust thin-film composite (TFC) membranes for ultrafast polar solvents filtration.  JOURNAL OF MEMBRANE SCIENCE,  685  (121961).  [PMID:]
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23. Wang Chuanfeng, Chen Yingbo, Wang Meng, Guo Renhao.  (2023)  Cross-Linked Dual-Layer Poly(vinylidene Fluoride) Hollow Fiber Membranes for Organic Solvent Nanofiltration.  FIBERS AND POLYMERS,  24  (1): (1-14).  [PMID:]
24. Qingjng Liang, Feng Yu, Hao Cai, Xiaoyan Wu, Menghui Ma, Zijian Li, Antonio Claudio Tedesco, Junfa Zhu, Qian Xu, Hong Bi.  (2023)  Photo-activated autophagy-associated tumour cell death by lysosome impairment based on manganese-doped graphene quantum dots.  Journal of Materials Chemistry B,  11  (11): (2466-2477).  [PMID:36843492]
25. Liang Wenfei, Nie Chengming, Du Jun, Han Yaoyao, Zhao Guohui, Yang Fan, Liang Guijie, Wu Kaifeng.  (2023)  Near-infrared photon upconversion and solar synthesis using lead-free nanocrystals.  Nature Photonics,  17  (4): (346-353).  [PMID:]
26. Huimin Liu, Kaixuan Wang, Yinfeng Ma, Yong Tian, Houpeng Zhang, Yu Wang, Chaofan Zhong.  (2023)  Novel Metal Complexes Unit of Phenanthroline Derivative for Being Used as Auxiliary Electron Acceptor in Dye Sensitizer Molecules.  EUROPEAN JOURNAL OF INORGANIC CHEMISTRY,  26  (15): (e202200647).  [PMID:]
27. Meng Kou, Feng Qin, Yongda Wang, Xiyu Zhang, Zheng Hu, Zhiguo Zhang.  (2023)  Insight into the Heavy Atom Effect Induced by Environmental Heavy Atoms for Gadolinium-Labeled Hematoporphyrin Monomethyl Ether.  JOURNAL OF PHYSICAL CHEMISTRY B,  127  (3): (777–782).  [PMID:36647797]
28. Wu Min, Huang Yuxin, Huang Xiaoyu, Wang Fu, Wei Xunbin.  (2023)  Copolymerized carbon nitride nanoparticles for near-infrared II photoacoustic-guided synergistic photothermal/radiotherapy.  Frontiers in Chemistry,  11    [PMID:36711234]
29. Qing Fang, Qin Liu, Zongli Xie, Matthew R. Hill, Kaisong Zhang.  (2023)  Two dimensional laminar MoS2 modified PTMSP membranes with improved organic solvent nanofiltration performance.  JOURNAL OF MEMBRANE SCIENCE,  666  (121139).  [PMID:]
30. Meudjeu Tognia, Guoqing Feng, Zonglin Pan, Xinfei Fan, Chengwen Song, Tonghua Wang.  (2022)  Efficient reactive electrochemical carbon membranes for organic pollutants removal from aqueous solution: A study of multi-physics modeling and simulation approach.  Journal of Water Process Engineering,  50  (103261).  [PMID:]
31. Mou Chen-Ye, Xie Yan-Fei, Wei Jia-Xin, Wang Qi-Yao, Le Jing-Yang, Bao Yong-Jie, Zhang Pan-Pan, Mao Yue-Chun, Huang Xing-Han, Pan Han-Bo, Naman C. Benjamin, Liu Lin, Liang Hong-Ze, Wu Xiang, Xu Jia, Cui Wei.  (2022)  Rose Bengal inhibits β-amyloid oligomers-induced tau hyperphosphorylation via acting on Akt and CDK5 kinases.  PSYCHOPHARMACOLOGY,  239  (11): (3579-3593).  [PMID:36221038]
32. Meng Kou, Feng Qin, Yongda Wang, Xiyu Zhang, Hua Zhao, Ye Tian, Zhiguo Zhang.  (2022)  Intrinsic Characterization Method on the Heavy Atom Effect of Metalloporphyrins.  INORGANIC CHEMISTRY,  61  (38): (15175–15181).  [PMID:36102614]
33. Jianqin Wan, Jiahao Liang, Shiyun Xian, Xiao Gong, Hangxiang Wang.  (2023)  Ultrasmall organosilica nanoparticles with strong solid-state fluorescence for multifunctional applications.  Journal of Advanced Research,  47  (93).  [PMID:35931324]
34. Meng Ding, Wei Zhao, Xu Zhang, Lingjie Song, Shifang Luan.  (2022)  Charge-switchable MOF nanocomplex for enhanced biofilm penetration and eradication.  JOURNAL OF HAZARDOUS MATERIALS,  439  (129594).  [PMID:35850068]
35. Xueqiu You, Wei Peng, Jia-Xing He, Jia-Sheng Lin, Xiao-Qi Zong, Nan Zhao, Jing-Liang Yang, Ming-De Li, Yue-Jiao Zhang, Jun Yi, Huaizhou Jin, Zhong-Qun Tian, Jian-Feng Li.  (2022)  Inhomogeneity of fluorescence lifetime and intensity in a plasmonic nanocavity.  Nano Today,  45  (101548).  [PMID:]
36. Chongchong Chen, Xiaoli Wu, Jie Zhang, Jingjing Chen, Xulin Cui, Wenpeng Li, Wenjia Wu, Jingtao Wang.  (2022)  Molecule transfer mechanism in two-dimensional heterostructured lamellar membranes: The effects of dissolution and diffusion.  AICHE JOURNAL,  68  (9): (e17795).  [PMID:]
37. Yuxiang Zhang, Wenzhen Liu, Yunmei Huang, Yanhuang Wang, Xueyuan Chen, Zhuo Chen.  (2022)  Bacterial biofilm microenvironment responsive copper-doped zinc peroxide nanocomposites for enhancing chemodynamic therapy.  CHEMICAL ENGINEERING JOURNAL,  446  (137214).  [PMID:]
38. Yuanzheng Zhang, Xiang Chen, Chao Liang, Lifeng Yin, Yang Yang.  (2022)  Reconstructing the coordination environment of single atomic Fe-catalysts for boosting the Fenton-like degradation activities.  APPLIED CATALYSIS B-ENVIRONMENTAL,  315  (121536).  [PMID:]
39. Jun Xiang, Huan Li, Yunhao Hei, Guiying Tian, Lei Zhang, Penggao Cheng, Jianping Zhang, Na Tang.  (2022)  Preparation of highly permeable electropositive nanofiltration membranes using quaternized polyethyleneimine for dye wastewater treatment.  Journal of Water Process Engineering,  48  (102831).  [PMID:]
40. Jun Wang, Ying Zhao, Chunting Li, Zijun Yu, Yang Zhang, Yuan Li, Xiaoyao Tan, Shaomin Liu, Shaobin Wang, Xiaoguang Duan.  (2022)  Peroxymonosulfate oxidation via paralleled nonradical pathways over iron and nitrogen doped porous carbons.  SCIENCE OF THE TOTAL ENVIRONMENT,  836  (155670).  [PMID:35523353]
41. Xuyou Yang, Junhui Huang, Fan Yang, Wenguang Wang, Caihong Xue, Wanji Zhou, Yadong Wu, Lu Shao, Yanqiu Zhang.  (2022)  Metal-organophosphate biphasic interfacial coordination reaction synthesizing nanofiltration membranes with the ultrathin selective layer, excellent acid-resistance and antifouling performance.  JOURNAL OF MEMBRANE SCIENCE,  653  (120521).  [PMID:]
42. Ye Xiwen, Jiang Yanxiao, Mu Xiaowei, Sun Ying, Ma Pinyi, Ren Ping, Song Daqian.  (2022)  Ultrabright silicon nanoparticle fluorescence probe for sensitive detection of cholesterol in human serum.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  414  (13): (3827-3836).  [PMID:35347354]
43. Jingjing Chen, Zhijie Yuan, Xiaoli Wu, Jingtao Wang, Yongpeng Yang, Wenpeng Li, Zhongyi Jiang.  (2022)  Molecule stratification in 2D heterostructured nanochannels towards enhanced selective permeation.  CHEMICAL ENGINEERING JOURNAL,  440  (135828).  [PMID:]
44. Anqi Wang, Wei Chen, Hang Xu, Zongli Xie, Xiaoying Zheng, Mingxiang Liu, Yueting Wang, Nannan Geng, Xiaoying Mu, Mingmei Ding.  (2022)  Heterostructured MoS2 quantum dot/GO lamellar membrane with improved transport efficiency for organic solvents inspired by the Namib Desert beetle.  JOURNAL OF MEMBRANE SCIENCE,  650  (120402).  [PMID:]
45. Jingjing Chen, Xiaoli Wu, Chongchong Chen, Yihao Chen, Wenpeng Li, Jingtao Wang.  (2022)  Secondary-assembled defect-free MOF membrane via triple-needle electrostatic atomization for highly stable and selective organics permeation.  JOURNAL OF MEMBRANE SCIENCE,  648  (120382).  [PMID:]
46. Longming Jin, Lijie Hu, Songmiao Liang, Zhiliang Wang, Guoyang Xu, Xingsheng Yang.  (2022)  A novel organic solvent nanofiltration (OSN) membrane fabricated by Poly(m-phenylene isophthalamide) (PMIA) under large-scale and continuous process.  JOURNAL OF MEMBRANE SCIENCE,  647  (120259).  [PMID:]
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References

1. Abdul Ghaffar, Muhammad Hassan, Oleksiy V. Penkov, Cafer T. Yavuz, Kemal Celebi.  (2023)  Tunable Molecular Sieving by Hierarchically Assembled Porous Organic Cage Membranes with Solvent-Responsive Switchable Pores.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,  57  (48): (20380–20391).  [PMID:37965815]
2. Jin-Bo Li, Cheng-Ye Zhu, Bian-Bian Guo, Chang Liu, Jia-Hui Xin, Chao Zhang, Jian Wu, Lin Zhang, Hao-Cheng Yang, Zhi-Kang Xu.  (2024)  Ultrahigh-permeance polyamide thin-film composite membranes enabled by interfacial polymerization on a macro-porous substrate toward organic solvent nanofiltration.  JOURNAL OF MEMBRANE SCIENCE,  693  (122342).  [PMID:]
3. Wenjing Geng, Zechen Zhang, Qi Guo, Yuchen Liu, Xinxin Ye, Hui Zhang, Chen Fu, Fengguang Liu, Yujun Zhu, Cheng Chen.  (2023)  Tailoring graphene oxide nanofiltration membrane with adjustable nanochannels for enhanced molecule separation.  CHEMICAL ENGINEERING JOURNAL,  478  (27): (147327).  [PMID:9732876]
4. Liying Pan, Shihua Wang, Mintao Xie, Manshan Liang, Lichao Yu, Bing Du, Xiaoxia Ye, Yanshu Luo, Yun-Yun Quan, Zu-Sheng Huang.  (2023)  Biotin receptor and mitochondria dual targeted AIE photosensitizer for fluorescence imaging guided photodynamic anticancer therapy.  MATERIALS & DESIGN,  235  (26): (112441).  [PMID:16510448]
5. Zhe Wang, Yansha Zeng, Yue Shen, Qiyin Tan, Jiahao Sun, Jiaheng Teng, Hongjun Lin.  (2024)  Innovative integration of porous materials and membranes: Achieving optimized pore orientation for enhanced performance.  JOURNAL OF MEMBRANE SCIENCE,  689  (1): (122158).  [PMID:31434731]
6. Yanling Xiao, Yuying Yuan, Manshan Liang, Jiahao Ni, Lichao Yu, Zu-Sheng Huang, Bing Du, Yun-Yun Quan.  (2023)  Efficient type Ⅰ and type Ⅱ ROS generated aggregation-induced emission photosensitizer for mitochondria targeted photodynamic therapy.  DYES AND PIGMENTS,  220  (8): (111765).  [PMID:19920177]
7. Dong Yangbo, Feng Danyang, Li Wei, Zhang Rui, Dou Shuzhen, Wang Luoqi, Yang Yan, Wang Li, Yang Yang, Wei Feng, Qiao Zhen-An.  (2023)  Interfacial co-assembly strategy towards gradient mesoporous hollow sheet for molecule filtration.  NPG Asia Materials,  15  (1): (1-8).  [PMID:10961885]
8. Heguo Han, Chi Zhang, Huiting Yu, Zheng Liu, Jing Guo, Qifeng Zhang, Yuxuan Sun, Shenghai Li, Suobo Zhang.  (2023)  A novel organic solvent nanofiltration membrane prepared via green mild and simple crosslinking process.  JOURNAL OF MEMBRANE SCIENCE,  688  (122151).  [PMID:19185582]
9. Qing Fang, Qin Liu, Zongli Xie, Matthew R. Hill, Kaisong Zhang.  (2024)  Ultra-thin PTMSP nanocomposite membranes incorporated with functionalized MoS2 nanosheets for pharmaceutical concentration and solvent recovery.  SEPARATION AND PURIFICATION TECHNOLOGY,  330  (125296).  [PMID:16479015]
10. Jiayi Wu, Qin Liu, Yan Wang.  (2024)  Robust thin film composite membrane with Cu2+ integrally-crosslinking for organic solvent nanofiltration.  SEPARATION AND PURIFICATION TECHNOLOGY,  330  (29): (125229).  [PMID:12702766]
11. Yan-Zi Wang, Xin-Li An, Xiao-Ting Fan, Qiang Pu, Hu Li, Wen-Zhen Liu, Zhuo Chen, Jian-Qiang Su.  (2024)  Visible light-activated photosensitizer inhibits the plasmid-mediated horizontal gene transfer of antibiotic resistance genes.  JOURNAL OF HAZARDOUS MATERIALS,  461  (132564).  [PMID:37734313]
12. Kaili Huo, Jin Wang, Jianguo Zhang, Yuqiang Zhao, Shanjun Liu, Mengmeng Dou, Xiaoyue Wang, Qingyun Zhang, Chao Han, Wubin Wang, Chaoxu Zhou, Yahui Xu.  (2023)  Fabrication of a novel composite nanofiltration membrane with effective treating dye wastewater via integration of phase inversion and interfacial polymerization.  Journal of Environmental Chemical Engineering,  11  (111013).  [PMID:26779609]
13. Hongying Li, Fei Shi, Shuhui Chen, Yifan Li.  (2024)  Organic-inorganic hybrid two-dimensional membranes with enhanced solvent flux and stability.  SEPARATION AND PURIFICATION TECHNOLOGY,  328  (12): (124917).  [PMID:16517606]
14. Chao Han, Huan Liu, Yida Wang, Fuxin Zheng, Gang Han, Yan Wang.  (2023)  Thermal crosslinking and cyclodehydration assisted fabrication of chemically robust thin-film composite (TFC) membranes for ultrafast polar solvents filtration.  JOURNAL OF MEMBRANE SCIENCE,  685  (121961).  [PMID:]
15. Ke Xue, Yongfei Zhao, Saidong Sun, Yuanhang Li, Jiankang Liang, Zhengjian Qi.  (2023)  NIR-AIEgens nanospheres featuring high-fidelity dynamic lipid droplet targeting, expediting ferroptosis to annihilating tumor in hypoxia.  CHEMICAL ENGINEERING JOURNAL,  470  (144125).  [PMID:]
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Solution Calculators