| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| R649032-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $190.90 |
| Synonyms | Roslin 2|29574-21-8|Roslin-2|1-Benzyl-3,5,7-triaza-1-azoniaadamantane bromide|1-(Phenylmethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.1~3,7~]decane bromide, 1-Benzyl-1,3,5,7-tetraazatricyclo[3.3.1.1~3,7~] decane bromide, 1-Benzyl-3,5,7-triaza-1-azoniaadamant |
|---|---|
| Specifications & Purity | ≥99.0% |
| Storage Temp | Store at -20°C,Desiccated |
| Shipped In | Ice chest + Ice pads |
| Product Description | Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator with anticancer effects. Roslin 2 bromide binds FAK , disrupts the binding of FAK and p53. In Vitro Roslin 2 bromide decreases cancer cell viability and clonogenicity in a p53-dependent manner. Roslin 2 bromide increases p53 transcriptional activity that is inhibited by FAK using p21, Mdm-2, and Bax-promoter targets. Roslin 2 bromide also causes increased expression of p53 targets: p21, Mdm-2 and Bax proteins. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Roslin 2 (60 mg/kg; i.p; 5 days/week) bromide significantly decreases tumor growth, disrupts the complex of FAK and p53, and up-regulates p21 in HCT116 p53 +/+ but not in HCT116 p53 -/- xenografts in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid |
| IUPAC Name | 1-benzyl-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane;bromide |
|---|---|
| INCHI | InChI=1S/C13H19N4.BrH/c1-2-4-13(5-3-1)6-17-10-14-7-15(11-17)9-16(8-14)12-17;/h1-5H,6-12H2;1H/q+1;/p-1 |
| InChi Key | YJMKPGPWDHCYCD-UHFFFAOYSA-M |
| Canonical SMILES | C1N2CN3CN1C[N+](C2)(C3)CC4=CC=CC=C4.[Br-] |
| Isomeric SMILES | C1N2CN3CN1C[N+](C2)(C3)CC4=CC=CC=C4.[Br-] |
| WGK Germany | 3 |
| PubChem CID | 10519060 |
| Molecular Weight | 311.22 |
Enter Lot Number to search for COA:
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| RIDADR | NONHforallmodesoftransport |
