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Rosmarinic acid - 97%, high purity , CAS No.20283-92-5

  • ≥97%
Item Number
R109805
Grouped product items
SKUSizeAvailabilityPrice Qty
R109805-250mg
250mg
In stock
$19.90
R109805-1g
1g
In stock
$59.90
R109805-5g
5g
In stock
$228.90
R109805-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,030.90

GPR35 agonist; anti-inflammatory, cytostatic and antiviral

Basic Description

Synonymsrosmarinic acid|20283-92-5|Rosemary acid|Labiatenic acid|Rosmarinicacid|Labiatic acid|(R)-rosmarinic acid|trans-Rosmarinic acid|Rosemaric acid|Rosmarinic acid racemate|Rosmarinate|Rosmarinic-acid|UNII-MQE6XG29YI|MQE6XG29YI|CCRIS 9361|RM 21A|537-15-5|ORIST
Specifications & Purity97%
Storage TempArgon charged
Shipped InNormal
Product Description

An activator of GPR35.

Associated Targets

SNCA Tchem Alpha-synuclein 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488195247
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488195247
IUPAC Name (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid
INCHI InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
InChi Key DOUMFZQKYFQNTF-WUTVXBCWSA-N
Canonical SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2
Isomeric SMILES C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)O)O
WGK Germany 3
PubChem CID 5281792
Molecular Weight 360.31
Beilstein 2227587

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

22 results found

Lot NumberCertificate TypeDateItem
G2431504Certificate of AnalysisAug 07, 2024 R109805
G2431503Certificate of AnalysisAug 07, 2024 R109805
G2431502Certificate of AnalysisAug 07, 2024 R109805
E2423421Certificate of AnalysisMay 31, 2024 R109805
E2423422Certificate of AnalysisMay 31, 2024 R109805
D2424358Certificate of AnalysisMar 08, 2024 R109805
B2421390Certificate of AnalysisMar 04, 2024 R109805
B2421389Certificate of AnalysisMar 04, 2024 R109805
D2418053Certificate of AnalysisMar 04, 2024 R109805
J2327667Certificate of AnalysisNov 01, 2023 R109805
J2327666Certificate of AnalysisNov 01, 2023 R109805
J2327605Certificate of AnalysisNov 01, 2023 R109805
J2327604Certificate of AnalysisNov 01, 2023 R109805
J2311081Certificate of AnalysisOct 19, 2023 R109805
F2316809Certificate of AnalysisJul 04, 2023 R109805
C2330801Certificate of AnalysisApr 11, 2023 R109805
C2330800Certificate of AnalysisApr 11, 2023 R109805
C2330797Certificate of AnalysisApr 11, 2023 R109805
C2330796Certificate of AnalysisApr 11, 2023 R109805
G2227482Certificate of AnalysisJul 30, 2022 R109805
G2227480Certificate of AnalysisJul 30, 2022 R109805
D2110068Certificate of AnalysisApr 25, 2021 R109805

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Chemical and Physical Properties

SolubilitySolvent:water, Max Conc. mg/mL: None, Max Conc. mM: 100
SensitivityAir Sensitive
Melt Point(°C)171-175°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS09
Signal Danger
Hazard Statements

H301:Toxic if swallowed

H400:Very toxic to aquatic life

Precautionary Statements

P273:Avoid release to the environment.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P391:Collect spillage.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

WGK Germany 3

Related Documents

References

1. Maike Petersen,Monique S J Simmonds.  (2002-12-17)  Rosmarinic acid..  Phytochemistry,  62  ((2)): (121-125).  [PMID:12482446]
2. Josefin Larsson,Johan Gottfries,Lars Bohlin,Anders Backlund.  (2005-07-26)  Expanding the ChemGPS chemical space with natural products..  Journal of natural products,  68  ((7)): (985-991).  [PMID:16038536]
3. Bianca Sperl,Markus H J Seifert,Thorsten Berg.  (2009-05-12)  Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains..  Bioorganic & medicinal chemistry letters,  19  ((12)): (3305-3309).  [PMID:19427202]
4. Ashley A Reinke,Han Yiau Seh,Jason E Gestwicki.  (2009-07-31)  A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta..  Bioorganic & medicinal chemistry letters,  19  ((17)): (4952-4957).  [PMID:19640715]
5. Teresa Mencherini,Patrizia Picerno,Paola Russo,Marisa Meloni,Rita Aquino.  (2009-08-06)  Composition of the fresh leaves and stems of Melissa officinalis and evaluation of skin irritation in a reconstituted human epidermis model..  Journal of natural products,  72  ((8)): (1512-1515).  [PMID:19653667]
6. Victor P Bulgakov,Yuliya V Inyushkina,Sergey A Fedoreyev.  (2011-08-16)  Rosmarinic acid and its derivatives: biotechnology and applications..  Critical reviews in biotechnology,  32  ((3)): (203-217).  [PMID:21838541]
7. G Mariappan,N Sundaraganesan,S Manoharan.  (2012-07-14)  Experimental and theoretical spectroscopic studies of anticancer drug rosmarinic acid using HF and density functional theory..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  97  (340-351).  [PMID:22789527]
8. Yuhang Chen,Qiaosheng Guo,Li Liu,Chengya Wang.  (2012-07-17)  [Influence of storage period and grading standards on quality of Prunella vulgaris]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  37  ((7)): (882-886).  [PMID:22792781]
9. Ying Zhang,Jonathan P Smuts,Edra Dodbiba,Rekha Rangarajan,John C Lang,Daniel W Armstrong.  (2012-08-14)  Degradation study of carnosic acid, carnosol, rosmarinic acid, and rosemary extract (Rosmarinus officinalis L.) assessed using HPLC..  Journal of agricultural and food chemistry,  60  ((36)): (9305-9314).  [PMID:22881034]
10. Maria J Jordán,Vanesa Lax,Maria C Rota,Susana Lorán,José A Sotomayor.  (2012-09-11)  Relevance of carnosic acid, carnosol, and rosmarinic acid concentrations in the in vitro antioxidant and antimicrobial activities of Rosmarinus officinalis (L.) methanolic extracts..  Journal of agricultural and food chemistry,  60  ((38)): (9603-9608).  [PMID:22957812]
11. Kazunori Sasaki,Abdelfatteh El Omri,Shinji Kondo,Junkyu Han,Hiroko Isoda.  (2012-10-23)  Rosmarinus officinalis polyphenols produce anti-depressant like effect through monoaminergic and cholinergic functions modulation..  Behavioural brain research,  238  (86-94).  [PMID:23085339]
12. Marina Zadra,Mariana Piana,Thiele Faccim de Brum,Aline Augusti Boligon,Robson Borba de Freitas,Michel Mansur Machado,Sílvio Terra Stefanello,Félix Alexandre Antunes Soares,Margareth Linde Athayde.  (2012-10-26)  Antioxidant Activity and phytochemical composition of the leaves of Solanum guaraniticum A. St.-Hil..  Molecules (Basel, Switzerland),  17  ((11)): (12560-12574).  [PMID:23095898]
13. .  ()  Rosmarinic acid ameliorates acute liver damage and fibrogenesis in carbon tetrachloride-intoxicated mice..  Food and chemical toxicology : an international journal published for the British Industri,      [PMID:23116643]
14. Jingyu Wang,Xueru Pan,Yi Han,Daosen Guo,Qunqun Guo,Ronggui Li.  (2012-12-04)  Rosmarinic acid from eelgrass shows nematicidal and antibacterial activities against pine wood nematode and its carrying bacteria..  Marine drugs,  10  ((12)): (2729-2740).  [PMID:23201594]
15. Pedro L Falé,Lia Ascensão,Maria L M Serralheiro.  (2012-12-12)  Effect of luteolin and apigenin on rosmarinic acid bioavailability in Caco-2 cell monolayers..  Food & function,  ((3)): (426-431).  [PMID:23223784]
16. Anja Klančnik,Sonja Smole Možina,Qijing Zhang.  (2013-01-04)  Anti-Campylobacter activities and resistance mechanisms of natural phenolic compounds in Campylobacter..  PloS one,  ((12)): (e51800-e51800).  [PMID:23284770]
17. Debleena Roy,Sandip Mukhopadhyay.  (2013-01-12)  Enhanced rosmarinic acid production in cultured plants of two species of Mentha..  Indian journal of experimental biology,  50  ((11)): (817-825).  [PMID:23305033]
18. Sung-Yong Yang,Chung-Oui Hong,Gung Pyo Lee,Cheong-Tae Kim,Kwang-Won Lee.  (2013-01-12)  The hepatoprotection of caffeic acid and rosmarinic acid, major compounds of Perilla frutescens, against t-BHP-induced oxidative liver damage..  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,  55  (92-99).  [PMID:23306788]
19. Zhao-Dong Xu,Jiang-Xiong Yao,Ju-Yan Liu,Chun Li,Li-Mei Lin.  (2013-01-17)  [Study on HPLC fingerprint of Prunella vulgaris]..  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials,  35  ((8)): (1234-1237).  [PMID:23320353]
20. Yitong Liu,Thomas J Flynn,Martine S Ferguson,Erica M Hoagland.  (2013-02-06)  Use of the Combination Index to determine interactions between plant-derived phenolic acids on hepatotoxicity endpoints in human and rat hepatoma cells..  Phytomedicine : international journal of phytotherapy and phytopharmacology,  20  ((5)): (461-468).  [PMID:23380082]
21. Luciana Garros Ferreira,Andrea Carla Celotto,Verena Kise Capellini,Agnes Afrodite Sumarelli Albuquerque,Tales Rubens de Nadai,Marco Tulio Menezes de Carvalho,Paulo Roberto Barbosa Evora.  (2013-02-13)  Is rosmarinic acid underestimated as an experimental cardiovascular drug?.  Acta cirurgica brasileira,  28 Suppl 1  (83-87).  [PMID:23381830]
22. Juan C Argoti,Pablo J Linares-Palomino,Sofía Salido,Bernardo Ramírez,Braulio Insuasty,Joaquín Altarejos.  (2013-02-19)  On-line activity screening for radical scavengers from Baccharis chilco..  Chemistry & biodiversity,  10  ((2)): (189-197).  [PMID:23418166]
23. Juan A Martín,Johanna Witzell,Kathrin Blumenstein,Elzbieta Rozpedowska,Marjo Helander,Thomas N Sieber,Luis Gil.  (2013-03-08)  Resistance to Dutch elm disease reduces presence of xylem endophytic fungi in Elms (Ulmus spp.)..  PloS one,  ((2)): (e56987-e56987).  [PMID:23468900]
24. Su-Jin Kim,Jae-Young Um,Sung-Hoon Kim,Seung-Heon Hong.  (2013-04-04)  Protective effect of rosmarinic acid is through regulation of inflammatory cytokine in cadmium-induced ototoxicity..  The American journal of Chinese medicine,  41  ((2)): (391-404).  [PMID:23548128]
25. Rodrigo Lucarini,Wagner A Bernardes,Daniele S Ferreira,Marcos G Tozatti,Ricardo Furtado,Jairo K Bastos,Patrícia M Pauletti,Ana H Januário,Márcio L Andrade E Silva,Wilson R Cunha.  (2013-06-07)  In vivo analgesic and anti-inflammatory activities of Rosmarinus officinalis aqueous extracts, rosmarinic acid and its acetyl ester derivative..  Pharmaceutical biology,  51  ((9)): (1087-1090).  [PMID:23738822]
26. Xiang Jin,Peng Liu,Fengchi Yang,Ya-Hong Zhang,Danmin Miao.  (2013-06-13)  Rosmarinic acid ameliorates depressive-like behaviors in a rat model of CUS and Up-regulates BDNF levels in the hippocampus and hippocampal-derived astrocytes..  Neurochemical research,  38  ((9)): (1828-1837).  [PMID:23756732]
27. N Mihailovic-Stanojevic,A Belščak-Cvitanović,J Grujić-Milanović,M Ivanov,Dj Jovović,D Bugarski,Z Miloradović.  (2013-07-06)  Antioxidant and antihypertensive activity of extract from Thymus serpyllum L. in experimental hypertension..  Plant foods for human nutrition (Dordrecht, Netherlands),  68  ((3)): (235-240).  [PMID:23828496]
28. Jun-Feng Gao,Ling Ding,Peng Zhang,Jian-Xun Liu.  (2013-08-21)  [Chemical constituents of Salvia chinensis]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  38  ((10)): (1556-1559).  [PMID:23947137]
29. Ranabir Sahu,Saikat Dewanjee,Moumita Gangopadhyay.  (2013-11-28)  Bioproduction and optimization of rosmarinic acid production in Solenostemon scutellarioides through media manipulation and conservation of high yielding clone via encapsulation..  Natural product communications,  ((9)): (1275-1278).  [PMID:24273865]
30. Z Su,X Wang,X Gao,Y Liu,C Pan,H Hu,R P Beyer,M Shi,J Zhou,J Zhang,A L Serra,R P Wüthrich,C Mei.  (2014-02-06)  Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease..  Journal of internal medicine,  276  ((5)): (470-485).  [PMID:24494798]
31. Renata Kubínová,Radka Pořízková,Alice Navrátilová,Oldřich Farsa,Zuzana Hanáková,Adriana Bačinská,Alois Cížek,Marie Valentová.  (2014-02-11)  Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth..  Journal of enzyme inhibition and medicinal chemistry,  29  ((5)): (749-752).  [PMID:24506206]
32. Akram Astani,Mojdeh Heidary Navid,Paul Schnitzler.  (2014-05-13)  Attachment and penetration of acyclovir-resistant herpes simplex virus are inhibited by Melissa officinalis extract..  Phytotherapy research : PTR,  28  ((10)): (1547-1552).  [PMID:24817544]
33. O Kenny,T J Smyth,D Walsh,C T Kelleher,C M Hewage,N P Brunton.  (2014-05-20)  Investigating the potential of under-utilised plants from the Asteraceae family as a source of natural antimicrobial and antioxidant extracts..  Food chemistry,  161  (79-86).  [PMID:24837924]
34. Hadi Ghaffari,M Venkataramana,Behrouz Jalali Ghassam,S Chandra Nayaka,A Nataraju,N P Geetha,H S Prakash.  (2014-07-25)  Rosmarinic acid mediated neuroprotective effects against H2O2-induced neuronal cell damage in N2A cells..  Life sciences,  113  ((1-2)): (7-13).  [PMID:25058919]
35. Sarah E Bloch,Claudia Schmidt-Dannert.  (2014-09-11)  Construction of a chimeric biosynthetic pathway for the de novo biosynthesis of rosmarinic acid in Escherichia coli..  Chembiochem : a European journal of chemical biology,  15  ((16)): (2393-2401).  [PMID:25205019]
36. Supattra Rungsimakan,Michael G Rowan.  (2014-09-27)  Terpenoids, flavonoids and caffeic acid derivatives from Salvia viridis L. cvar. Blue Jeans..  Phytochemistry,  108  (177-188).  [PMID:25256822]
37. Ana Mara de Oliveira E Silva,Isabel Daufenback Machado,José Roberto Santin,Illana Louise Pereira de Melo,Gabriela Vieira Pedrosa,Maria Ines Genovese,Sandra Helena Poliselli Farsky,Jorge Mancini-Filho.  (2014-10-17)  Aqueous extract of Rosmarinus officinalis L. inhibits neutrophil influx and cytokine secretion..  Phytotherapy research : PTR,  29  ((1)): (125-133).  [PMID:25319517]
38. Juana I Mosele,Sandra Martín-Peláez,Alba Macià,Marta Farràs,Rosa-Maria Valls,Úrsula Catalán,María-José Motilva.  (2014-10-24)  Study of the catabolism of thyme phenols combining in vitro fermentation and human intervention..  Journal of agricultural and food chemistry,  62  ((45)): (10954-10961).  [PMID:25339317]
39. Hayato Urushima,Junichi Nishimura,Tsunekazu Mizushima,Noriyuki Hayashi,Kazuhisa Maeda,Toshinori Ito.  (2014-11-02)  Perilla frutescens extract ameliorates DSS-induced colitis by suppressing proinflammatory cytokines and inducing anti-inflammatory cytokines..  American journal of physiology. Gastrointestinal and liver physiology,  308  ((1)): (G32-G41).  [PMID:25359539]
40. Burcu Bekdeşer,Nazan Durusoy,Mustafa Özyürek,Kubilay Güçlü,Reşat Apak.  (2014-11-05)  Optimization of microwave-assisted extraction of polyphenols from herbal teas and evaluation of their in vitro hypochlorous acid scavenging activity..  Journal of agricultural and food chemistry,  62  ((46)): (11109-11115).  [PMID:25365495]
41. Ji-Won Lee,Midori Asai,Sang-Kyung Jeon,Tadahiro Iimura,Takayuki Yonezawa,Byung-Yoon Cha,Je-Tae Woo,Akira Yamaguchi.  (2014-11-08)  Rosmarinic acid exerts an antiosteoporotic effect in the RANKL-induced mouse model of bone loss by promotion of osteoblastic differentiation and inhibition of osteoclastic differentiation..  Molecular nutrition & food research,  59  ((3)): (386-400).  [PMID:25380345]
42. Hakryul Jo,Victoria Patterson,Sean Stoessel,Chia-Yi Kuan,Josephine Hoh.  (2014-12-17)  Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease..  PloS one,  ((12)): (e115362-e115362).  [PMID:25506911]
43. Xuelin Zhou,Ching Mei Cheung,Jia-Ming Yang,Penelope M Y Or,Wayne Y W Lee,John H K Yeung.  (2015-02-04)  Danshen (Salvia miltiorrhiza) water extract inhibits paracetamol-induced toxicity in primary rat hepatocytes via reducing CYP2E1 activity and oxidative stress..  The Journal of pharmacy and pharmacology,  67  ((7)): (980-989).  [PMID:25645193]
44. Meijuan Li,Fengqing Wang,Yühong Huang,Feifei Du,Chenchun Zhong,Olajide E Olaleye,Weiwei Jia,Yanfen Li,Fang Xu,Jiajia Dong,Jian Li,Justin B R Lim,Buchang Zhao,Lifu Jia,Li Li,Chuan Li.  (2015-02-12)  Systemic exposure to and disposition of catechols derived from Salvia miltiorrhiza roots (Danshen) after intravenous dosing DanHong injection in human subjects, rats, and dogs..  Drug metabolism and disposition: the biological fate of chemicals,  43  ((5)): (679-690).  [PMID:25670806]
45. Milica Vujicic,Ivana Nikolic,Vassiliki G Kontogianni,Tamara Saksida,Pantelis Charisiadis,Zorana Orescanin-Dusic,Dusko Blagojevic,Stanislava Stosic-Grujicic,Andreas G Tzakos,Ivana Stojanovic.  (2015-02-12)  Methanolic extract of Origanum vulgare ameliorates type 1 diabetes through antioxidant, anti-inflammatory and anti-apoptotic activity..  The British journal of nutrition,  113  ((5)): (770-782).  [PMID:25671817]
46. Luana Chiquetto Paracatu,Carolina Maria Quinello Gomes de Faria,Maria Luiza Zeraik,Camila Quinello,Camila Rennó,Patrícia Palmeira,Luiz Marcos da Fonseca,Valdecir Farias Ximenes.  (2015-05-01)  Hydrophobicity and antioxidant activity acting together for the beneficial health properties of nordihydroguaiaretic acid..  Food & function,  ((6)): (1818-1831).  [PMID:25927268]
47. Hana Moon,Min Jung Kim,Hee Jin Son,Hae-Jin Kweon,Jung Tae Kim,Yiseul Kim,Jaewon Shim,Byung-Chang Suh,Mee-Ra Rhyu.  (2015-05-16)  Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa..  PloS one,  10  ((5)): (e0127060-e0127060).  [PMID:25978436]
48. M Jacotet-Navarro,N Rombaut,A-S Fabiano-Tixier,M Danguien,A Bily,F Chemat.  (2015-07-19)  Ultrasound versus microwave as green processes for extraction of rosmarinic, carnosic and ursolic acids from rosemary..  Ultrasonics sonochemistry,  27  (102-109).  [PMID:26186826]
49. Dieter Schemeth,Jean-Christophe Noël,Thomas Jakschitz,Matthias Rainer,Richard Tessadri,Christian W Huck,Günther K Bonn.  (2015-08-02)  Poly(N-vinylimidazole/ethylene glycol dimethacrylate) for the purification and isolation of phenolic acids..  Analytica chimica acta,  885  (199-206).  [PMID:26231906]
50. Sylwester Slusarczyk,Jakub Topolski,Krzysztof Domaradzki,Michael Adams,Matthias Hamburger,Adam Matkowski.  (2015-09-29)  Isolation and Fast Selective Determination of Nor-abietanoid Diterpenoids from Perovskia atriplicifolia Roots Using LC-ESI-MS/MS with Multiple Reaction Monitoring..  Natural product communications,  10  ((7)): (1149-1152).  [PMID:26410997]
51. Saliha Esin Çelik,Ayse Nur Tufan,Burcu Bekdeser,Mustafa Özyürek,Kubilay Güçlü,Resat Apak.  (2016-11-26)  Identification and Determination of Phenolics in Lamiaceae Species by UPLC-DAD-ESI-MS/MS..  Journal of chromatographic science,  55  ((3)): (291-300).  [PMID:27884875]
52. Andrea Civra,Rachele Francese,Davide Sinato,Manuela Donalisio,Valeria Cagno,Patrizia Rubiolo,Ramazan Ceylan,Ahmet Uysal,Gokhan Zengin,David Lembo.  (2017-01-26)  In vitro screening for antiviral activity of Turkish plants revealing methanolic extract of Rindera lanata var. lanata active against human rotavirus..  BMC complementary and alternative medicine,  17  ((1)): (74-74).  [PMID:28118832]
53. Yan Zhang,Min Hu,Liu Liu,Xiao-Ling Cheng,Jing Cai,Jian Zhou,Tao Wang.  (2018-07-14)  Anticancer effects of Rosmarinic acid in OVCAR-3 ovarian cancer cells are mediated via induction of apoptosis, suppression of cell migration and modulation of lncRNA MALAT-1 expression..  Journal of B.U.ON. : official journal of the Balkan Union of Oncology,  23  ((3)): (763-768).  [PMID:30003749]
54. Meng-Ge Lv,Wen-Qiong Chen,Shi-Qi Weng,Hou-Yang Chen,Yi-Min Cheng,Tao Luo.  (2018-07-17)  Rosmarinic acid compromises human sperm functions by an intracellular Ca2+ concentration-related mechanism..  Reproductive toxicology (Elmsford, N.Y.),  81  (58-63).  [PMID:30009954]
55. Le Qu,Huamin Xu,Wenting Jia,Hong Jiang,Junxia Xie.  (2018-10-22)  Rosmarinic acid protects against MPTP-induced toxicity and inhibits iron-induced α-synuclein aggregation..  Neuropharmacology,  144  (291-300).  [PMID:30342981]
56. A Oğuz,A Böyük,A Ekinci,U Alabalik,A Türkoğlu,M C Tuncer,A Ekingen,E Deveci,B Gültürk,U Aday.  (2019-08-23)  Investigation of antioxidant effects of rosmarinic acid on liver, lung and kidney in rats: a biochemical and histopathological study..  Folia morphologica,  79  ((2)): (288-295).  [PMID:31436305]
57. Abdülmelik Aras,Ercan Bursal,Fikret Türkan,Hatice Tohma,Ömer Kılıç,İlhami Gülçin,Ekrem Köksal.  (2019-08-30)  Phytochemical Content, Antidiabetic, Anticholinergic, and Antioxidant Activities of Endemic Lecokia cretica Extracts..  Chemistry & biodiversity,  16  ((10)): (e1900341-e1900341).  [PMID:31465610]
58. Łukasz Sęczyk,Beata Król,Barbara Kołodziej.  (2020-01-10)  In vitro bioaccessibility and activity of Greek oregano (Origanum vulgare L. ssp. hirtum (link) Ietswaart) compounds as affected by nitrogen fertilization..  Journal of the science of food and agriculture,  100  ((6)): (2410-2417).  [PMID:31917463]
59. Chia-Hung Su,Thi Thanh Truc Pham,Hsien-Hao Cheng.  (2020-01-31)  Aqueous enzymatic extraction of rosmarinic acid from Salvia officinalis: optimisation using response surface methodology..  Phytochemical analysis : PCA,  31  ((5)): (575-582).  [PMID:31997419]
60. María Pilar de Torre,Jose Luis Vizmanos,Rita Yolanda Cavero,María Isabel Calvo.  (2020-06-22)  Improvement of antioxidant activity of oregano (Origanum vulgare L.) with an oral pharmaceutical form..  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,  129  (110424-110424).  [PMID:32563980]
61. Vieira, et al..  (2020)  Rosmarinic Acid Intravitreal Implants: A New Therapeutic Approach for Ocular Neovascularization..  Planta Medica,  86  (1286-1297).  [PMID:32797466]
62. Giedrius Miliauskas,Teris A van Beek,Pieter de Waard,Rimantas P Venskutonis,Ernst J R Sudhölter.  (2005-02-26)  Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR..  Journal of natural products,  68  ((2)): (168-172).  [PMID:15730237]
63. Dubravko Jelić,Boris Mildner,Sanja Kostrun,Krunoslav Nujić,Donatella Verbanac,Ognjen Culić,Roberto Antolović,Wolfgang Brandt.  (2007-02-24)  Homology modeling of human Fyn kinase structure: discovery of rosmarinic acid as a new Fyn kinase inhibitor and in silico study of its possible binding modes..  Journal of medicinal chemistry,  50  ((6)): (1090-1100).  [PMID:17315853]
64. Maike Petersen,Yana Abdullah,Johannes Benner,David Eberle,Katja Gehlen,Stephanie Hücherig,Verena Janiak,Kyung Hee Kim,Marion Sander,Corinna Weitzel,Stefan Wolters.  (2009-06-30)  Evolution of rosmarinic acid biosynthesis..  Phytochemistry,  70  ((15-16)): (1663-1679).  [PMID:19560175]
65. Aya Fujimoto,Yoshimi Shingai,Mitsuhiro Nakamura,Tomomi Maekawa,Yoshiaki Sone,Toshiya Masuda.  (2010-11-03)  A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol..  Bioorganic & medicinal chemistry letters,  20  ((24)): (7393-7396).  [PMID:21041086]
66. V Karthikkumar,G Sivagami,R Vinothkumar,D Rajkumar,N Nalini.  (2012-09-11)  Modulatory efficacy of rosmarinic acid on premalignant lesions and antioxidant status in 1,2-dimethylhydrazine induced rat colon carcinogenesis..  Environmental toxicology and pharmacology,  34  ((3)): (949-958).  [PMID:22960260]
67. Atikorn Panya,Ketinun Kittipongpittaya,Mickaël Laguerre,Christelle Bayrasy,Jérôme Lecomte,Pierre Villeneuve,D Julian McClements,Eric A Decker.  (2012-09-20)  Interactions between α-tocopherol and rosmarinic acid and its alkyl esters in emulsions: synergistic, additive, or antagonistic effect?.  Journal of agricultural and food chemistry,  60  ((41)): (10320-10330).  [PMID:22988974]
68. Eun-Ju Yang,Sae-Kwang Ku,Wonhwa Lee,Sangkyu Lee,Taeho Lee,Kyung-Sik Song,Jong-Sup Bae.  (2012-10-09)  Barrier protective effects of rosmarinic acid on HMGB1-induced inflammatory responses in vitro and in vivo..  Journal of cellular physiology,  228  ((5)): (975-982).  [PMID:23042518]
69. Fa-Rong Li,Yan-Yan Fu,Dan-Hong Jiang,Zhen Wu,Yang-Jing Zhou,Ling Guo,Zhong-Min Dong,Zhe-Zhi Wang.  (2013-02-21)  Reversal effect of rosmarinic acid on multidrug resistance in SGC7901/Adr cell..  Journal of Asian natural products research,  15  ((3)): (276-285).  [PMID:23421517]
70. Ivana Generalić Mekinić,Franko Burcul,Ivica Blazević,Danijela Skroza,Daniela Kerum,Visnja Katalinić.  (2013-06-07)  Antioxidative/acetylcholinesterase inhibitory activity of some Asteraceae plants..  Natural product communications,  ((4)): (471-474).  [PMID:23738456]
71. Milan Mladenović,Sanja Matić,Snežana Stanić,Slavica Solujić,Vladimir Mihailović,Nevena Stanković,Jelena Katanić.  (2013-08-27)  Combining molecular docking and 3-D pharmacophore generation to enclose the in vivo antigenotoxic activity of naturally occurring aromatic compounds: myricetin, quercetin, rutin, and rosmarinic acid..  Biochemical pharmacology,  86  ((9)): (1376-1396).  [PMID:23973524]
72. Inge M Westra,Dorenda Oosterhuis,Geny M M Groothuis,Peter Olinga.  (2013-12-11)  Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs..  Toxicology and applied pharmacology,  274  ((2)): (328-338).  [PMID:24321339]
73. Rong-Rong Cao,Xiao-Lin Dang,Bing-Yu Xing,Jing-Yi Zhang,Juan-E Dong.  (2014-02-05)  [Regulation effects of intracellular and extracellular Ca2+ on biosynthesis of rosmarinic acid induced by salicylic acid in young seedlings of Salvia miltiorrhiza]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  38  ((20)): (3424-3431).  [PMID:24490547]
74. Rekha Jakhar,Souren Paul,Anil Kumar Chauhan,Sun Chul Kang.  (2014-07-30)  Morin hydrate augments phagocytosis mechanism and inhibits LPS induced autophagic signaling in murine macrophage..  International immunopharmacology,  22  ((2)): (356-365).  [PMID:25068824]
75. Leila Maringer,Elena Ibáñez,Wolfgang Buchberger,Christian W Klampfl,Tim J Causon.  (2014-10-14)  Using sheath-liquid reagents for capillary electrophoresis-mass spectrometry: application to the analysis of phenolic plant extracts..  Electrophoresis,  36  ((2)): (348-354).  [PMID:25308871]
76. Jayanthy Govindaraj,Subramanian Sorimuthu Pillai.  (2015-03-05)  Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: streptozotocin-induced diabetic rats..  Molecular and cellular biochemistry,  404  ((1-2)): (143-159).  [PMID:25735949]
77. Naiani Ferreira Marques,Sílvio Terra Stefanello,Amanda L F Froeder,Alcindo Busanello,Aline Augusti Boligon,Margareth Linde Athayde,Félix A A Soares,Roselei Fachinetto.  (2015-04-24)  Centella asiatica and Its Fractions Reduces Lipid Peroxidation Induced by Quinolinic Acid and Sodium Nitroprusside in Rat Brain Regions..  Neurochemical research,  40  ((6)): (1197-1210).  [PMID:25903808]
78. Se Jin Park,Young Je Ahn,Hyung Eun Lee,Eunyoung Hong,Jong Hoon Ryu.  (2015-09-18)  Standardized Prunella vulgaris var. lilacina Extract Enhances Cognitive Performance in Normal Naive Mice..  Phytotherapy research : PTR,  29  ((11)): (1814-1821).  [PMID:26376910]
79. Jing Zhao,Xiaojing Du,Ni Cheng,Lanzhen Chen,Xiaofeng Xue,Jing Zhao,Liming Wu,Wei Cao.  (2015-10-17)  Identification of monofloral honeys using HPLC-ECD and chemometrics..  Food chemistry,  194  (167-174).  [PMID:26471540]
80. Juste Baranauskaite,Erika Adomavičiūtė,Virginija Jankauskaitė,Mindaugas Marksa,Zita Barsteigienė,Jurga Bernatoniene.  (2019-02-14)  Formation and Investigation of Electrospun Eudragit E100/Oregano Mats..  Molecules (Basel, Switzerland),  24  ((3)):   [PMID:30754653]
81. Bokyung Koo,Ho Jung Bae,Nayeon Goo,Jaehoon Kim,Jihyun Kim,Mudan Cai,In Ho Jung,Kyungnam Cho,Seo Yun Jung,Suk Woo Chang,Dae Sik Jang,Jong Hoon Ryu.  (2019-11-13)  A botanical drug composed of three herbal materials attenuates the sensorimotor gating deficit and cognitive impairment induced by MK-801 in mice..  The Journal of pharmacy and pharmacology,  72  ((1)): (149-160).  [PMID:31713882]
82. Chang Guo,Yu Shangguan,Meiru Zhang,Yanxin Ruan,Guoqing Xue,Jingfan Ma,Jian Yang,Longxin Qiu.  (2020-03-05)  Rosmarinic acid alleviates ethanol-induced lipid accumulation by repressing fatty acid biosynthesis..  Food & function,  11  ((3)): (2094-2106).  [PMID:32129352]
83. Yinyue Luo,Zhongjun Ma,Xiaoming Xu,Hongyan Qi,Zilu Cheng,Li Chen.  (2020-06-12)  Anticancer effects of rosmarinic acid in human oral cancer cells is mediated via endoplasmic reticulum stress, apoptosis, G2/M cell cycle arrest and inhibition of cell migration..  Journal of B.U.ON. : official journal of the Balkan Union of Oncology,  25  ((2)): (1245-1250).  [PMID:32521932]
84. Soyeon Hong,Kwang Hyun Cha,Do Yeon Kwon,Yang Ju Son,Sang Min Kim,Jung-Hye Choi,Gyhye Yoo,Chu Won Nho.  (2021-02-25)  Agastache rugosa ethanol extract suppresses bone loss via induction of osteoblast differentiation with alteration of gut microbiota..  Phytomedicine : international journal of phytotherapy and phytopharmacology,  84  (153517-153517).  [PMID:33626428]
85. Constant Anatole Pieme,Guru Kumar Santosh,Emmanuel Mouafo Tekwu,Tülin Askun,Hatice Aydeniz,Jeanne Yonkeu Ngogang,Shashi Bhushan,Ajit Kumar Saxena.  (2015-02-28)  Fruits and barks extracts of Zanthozyllum heitzii a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells..  Biological research,  47  (54-54).  [PMID:25723957]

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