Rovelizumab (anti-CD11a&CD18) - Primary antibody, specific to ITGAL; ITGB2, Human IgG4, Antibody of integrin; alpha L subunit (antigen CD11A (p180); lymphocyte function-associated antigen 1; alpha polypeptide);Antibody of integrin; beta 2 subunit (complement component 3 receptor 3 and 4 subunit)

Features and benefits

Short Overview:
Purity≥95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
Species reactivity(Reacts with): Human
Isotype: Human IgG4

Application:

Item Number

Ab175649

Grouped product items
SKU	Size	Availability	Price
Ab175649-100μg	100μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$69.90
Ab175649-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$339.90
Ab175649-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$869.90
Ab175649-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,379.90

Purity≥95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

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Basic Description

Product Name	Rovelizumab (anti-CD11a&CD18) - Primary antibody, specific to ITGAL; ITGB2, Human IgG4
Synonyms	Hu23F2G;LeukArrest
Specifications & Purity	ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot
Biochemical and Physiological Mechanisms	CD11a: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granuloc
Specificity	ITGAL; ITGB2
Conjugation	Unconjugated
Grade	Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action Type	ANTAGONIST
Mechanism of action	Antibody of integrin; alpha L subunit (antigen CD11A (p180); lymphocyte function-associated antigen 1; alpha polypeptide);Antibody of integrin; beta 2 subunit (complement component 3 receptor 3 and 4 subunit)
Product Description	Rovelizumab (anti-CD11a&CD18) is a humanized monoclonal leukointegrin antibody. Rovelizumab (anti-CD11a&CD18) is a monoclonal antibody directed against the CD11/CD18 cell adhesion proteins. Rovelizumab (anti-CD11a&CD18) can be used for research of multiple sclerosis (MS), hemorrhagic shock, myocardial infarction (MI) and stroke.

Product Properties

Isotype	Human IgG4
Light Chain Type	kappa
SDS-PAGE	145.98 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	Lot by Lot
Storage Temp	Store at -80°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS	339086-79-2

Associated Targets

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

References

1. Hu X, Wohler JE, Dugger KJ, Barnum SR. (2010) beta2-integrins in demyelinating disease: not adhering to the paradigm.. J Leukoc Biol, 87 (3): (397-403). [PMID:20007244]
2. Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW. (2005) ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow.. Blood, 106 (2): (584-92). [PMID:15811956]
3. Mazzone A, Ricevuti G. (1995) Leukocyte CD11/CD18 integrins: biological and clinical relevance.. Haematologica, 80 (2): (161-75). [PMID:7628754]
4. Yenari MA, Kunis D, Sun GH, Onley D, Watson L, Turner S, Whitaker S, Steinberg GK. (1998) Hu23F2G, an antibody recognizing the leukocyte CD11/CD18 integrin, reduces injury in a rabbit model of transient focal cerebral ischemia.. Exp Neurol, 153 (2): (223-33). [PMID:9784282]

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Basic Description