RRD-251 hydrochloride - 95%, high purity , CAS No.72214-67-6

Item Number

R338914

Grouped product items
SKU	Size	Availability	Price
R338914-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$49.90
R338914-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$89.90
R338914-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$197.90
R338914-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$316.90
R338914-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$499.90

a reversible selective disruptor of Rb/Raf-1 interaction

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Basic Description

Synonyms	72214-67-6\|RRD-251 hydrochloride\|2,4-dichlorobenzyl imidothiocarbamate hydrochloride\|RRD-251\|(2,4-dichlorophenyl)methyl carbamimidothioate;hydrochloride\|S-(2,4-Dichlorobenzyl)isothiourea Hydrochloride\|Rb/Raf-1 Disruptor 251\|DTXSID30992949\|NSC33208\|NSC3538
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Product Description	RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

Names and Identifiers

IUPAC Name	(2,4-dichlorophenyl)methyl carbamimidothioate;hydrochloride
INCHI	InChI=1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
InChi Key	COMNQRICZGJVLE-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C=C1Cl)Cl)CSC(=N)N.Cl
Isomeric SMILES	C1=CC(=C(C=C1Cl)Cl)CSC(=N)N.Cl
PubChem CID	12526767
Molecular Weight	271.59

Solubility

Soluble in DMSO: >10 mg/mL and Water: >2 mg/mL

Sensitivity

Moisture sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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Basic Description