Rucaparib camsylate - ≥98%(HPLC), high purity , PARP 1, 2 and 3 inhibitor, CAS No.1859053-21-6, PARP 1, 2 and 3 inhibitor

Item Number

R288628

Grouped product items
SKU	Size	Availability	Price
R288628-5mg	5mg	In stock	$68.90
R288628-10mg	10mg	In stock	$117.90
R288628-25mg	25mg	In stock	$265.90
R288628-50mg	50mg	In stock	$296.90
R288628-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$444.90

PARP inhibitor

Basic Description

Synonyms	41AX9SJ8KO \| 6,7-Dimethoxy-quinolin-4-ol;6,7-Dimethoxy-1H-quinolin-4-one \| AG14699 camsylate \| (4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino(5,4,3-cd)indol-2-yl)phenyl)-N-methylmethanaminium ((1S,4R)-7,7-dimethyl-2-oxobicyclo(2.2.1)heptan-1-yl)methanes
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	PARP inhibitor. Chemosensitization of colorectal cancer cells Totemozolomide and Topotecan. Rucaparib is an inhibitor of the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It has been found to have anticancer activity in a number of cancers and
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	PARP 1, 2 and 3 inhibitor

Names and Identifiers

IUPAC Name	[(1S,4R)-7,7-dimethyl-2-oxo-1-bicyclo[2.2.1]heptanyl]methanesulfonic acid;6-fluoro-2-[4-(methylaminomethyl)phenyl]-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13)-tetraen-9-one
INCHI	InChI=1S/C19H18FN3O.C10H16O4S/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15;1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);7H,3-6H2,1-2H3,(H,12,13,14)/t;7-,10-/m.1/s1
InChi Key	INBJJAFXHQQSRW-STOWLHSFSA-N
Canonical SMILES	CC1(C2CCC1(C(=O)C2)CS(=O)(=O)O)C.CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2
Isomeric SMILES	CC1([C@@H]2CC[C@]1(C(=O)C2)CS(=O)(=O)O)C.CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=C3C(=CC(=C4)F)N2
PubChem CID	121490161
Molecular Weight	555.66

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
C2214265	Certificate of Analysis	Feb 10, 2022	R288628
C2214266	Certificate of Analysis	Feb 10, 2022	R288628
C2214290	Certificate of Analysis	Feb 10, 2022	R288628
C2214291	Certificate of Analysis	Feb 10, 2022	R288628
C2214292	Certificate of Analysis	Feb 10, 2022	R288628

Safety and Hazards(GHS)

Pictogram(s)	GHS08
Signal	Warning
Hazard Statements	H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P201:Obtain special instructions before use. P308+P313:IF exposed or concerned: Get medical advice/attention. P202:Do not handle until all safety precautions have been read and understood.

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Basic Description