Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab183448-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $59.90 | |
| Ab183448-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $289.90 | |
| Ab183448-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $749.90 | |
| Ab183448-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,189.90 |
Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
| Product Name | Ruplizumab (anti-CD40L) - Primary antibody, specific to CD40LG, Human IgG1 |
|---|---|
| Specifications & Purity | ExactAb™, Validated, Carrier Free, Low Endotoxin, Azide Free, Recombinant, ≥95%(SDS-PAGE&SEC), Lot by Lot |
| Specificity | CD40LG |
| Conjugation | Unconjugated |
| Grade | Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | INHIBITOR of CD40 ligand inhibitor |
| Product Description | Ruplizumab (anti-CD40L) is a humanized monoclonal anti-CD40L (TNF Receptor) IgG1κ antibody. Ruplizumab (anti-CD40L) has the potential for systemic lupus erythematosus disease research. |
| Isotype | Human IgG1 |
|---|---|
| Light Chain Type | kappa |
| SDS-PAGE | 26.2 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 191.6 kDa, under non-reducing conditions. |
| Purification Method | Protein A purified |
| Form | Liquid |
| Concentration | Lot by Lot |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 220651-94-5 |
Ruplizumab (anti-CD40L) (Ab183448) - ELISA
Immobilized Recombinant Human CD40 Ligand protein (rp169583) at 2.0 μg/mL can bind Ruplizumab (anti-CD40L) (Ab183448) with the EC50 of 24.77 ng/mL.
Ruplizumab (anti-CD40L) (Ab183448) - Flow Cytometry
pLVX-puro-SYMX10-TNFSF5 (CD40L) - FL - HEK293 cells were stained with Ruplizumab (anti-CD40L) (Ab183448) and negative control protein respectively, washed and then followed by PE and analyzed with the FACS EC50 is 0.23 nM.
Ruplizumab (anti-CD40L) (Ab183448) - SEC
The purity of Ruplizumab (anti-CD40L) (Ab183448) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 ZJ24F0708359 | Certificate of Analysis | Jul 16, 2024 | Ab183448 |
| ZJ24F0708358 | Certificate of Analysis | Jul 16, 2024 | Ab183448 |
| ZJ24F0708357 | Certificate of Analysis | Jul 16, 2024 | Ab183448 |
