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RWJ-56423 , CAS No.R613342, Inhibitor of serine protease 1;Inhibitor of tryptase alpha/beta 1

Moligand™

PubChem CID: 5287596

Item Number

R613342

Grouped product items
SKU	Size	Availability	Price	Qty
R613342-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
R613342-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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serine protease 1 Inhibitor tryptase alpha/beta 1 Inhibitor

Synonyms

(2S)-6

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of serine protease 1;Inhibitor of tryptase alpha/beta 1

Associated Targets

TPSAB1 Tclin Tryptase alpha/beta-1 1 Activities

Discover Target: TPSAB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRSS1 Tclin Trypsin-1 1 Activities

Discover Target: PRSS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2S,4R)-1-acetyl-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-hydroxypyrrolidine-2-carboxamide
INCHI	InChI=1S/C20H26N6O4S/c1-11(27)26-10-12(28)9-15(26)18(30)24-14(6-4-8-23-20(21)22)17(29)19-25-13-5-2-3-7-16(13)31-19/h2-3,5,7,12,14-15,28H,4,6,8-10H2,1H3,(H,24,30)(H4,21,22,23)/t12-,14+,15+/m1/s1
InChi Key	VXDAVYUFYPFGDX-SNPRPXQTSA-N
Canonical SMILES	NC(=N)NCCC[C@@H](C(=O)c1nc2c(s1)cccc2)NC(=O)[C@@H]1C[C@H](CN1C(=O)C)O
Isomeric SMILES	CC(=O)N1C[C@@H](C[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)C2=NC3=CC=CC=C3S2)O
PubChem CID	5287596

PubChem CID

5287596

ChEMBL Ligand

CHEMBL256892

RCSB PDB Ligand

ABB

References

1. Costanzo MJ, Yabut SC, Almond Jr HR, Andrade-Gordon P, Corcoran TW, De Garavilla L, Kauffman JA, Abraham WM, Recacha R, Chattopadhyay D et al.. (2003) Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone.. J Med Chem, 46 (18): (3865-76). [PMID:12930148]
2. Erin EM, Leaker BR, Zacharasiewicz A, Higgins LA, Nicholson GC, Boyce MJ, de Boer P, Jones RC, Durham SR, Barnes PJ et al.. (2006) Effects of a reversible beta-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses.. Clin Exp Allergy, 36 (4): (458-64). [PMID:16630150]

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RWJ-56423 , CAS No.R613342, Inhibitor of serine protease 1;Inhibitor of tryptase alpha/beta 1

Basic Description

Associated Targets

TPSAB1 Tclin Tryptase alpha/beta-1 1 Activities

PRSS1 Tclin Trypsin-1 1 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

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Dilution Calculator

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