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R275320-1mg

1mg

Available within 8-12 weeks(?)

$633.90

Basic Description

Synonyms	ryanodine\|15662-33-6\|Ryanodin\|Ryanodol, 3-(1H-pyrrole-2-carboxylate)\|[(1R,2R,3S,6S,7S,9S,10R,11S,12R,13S,14R)-2,6,9,11,13,14-hexahydroxy-3,7,10-trimethyl-11-propan-2-yl-15-oxapentacyclo[7.5.1.01,6.07,13.010,14]pentadecan-12-yl] 1H-pyrrole-2-carboxylate\|[(
Specifications & Purity	≥98%
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ACTIVATOR, CHANNEL BLOCKER
Mechanism of action	Activator of RyR1;Channel blocker of RyR1;Activator of RyR2;Channel blocker of RyR2;Activator of RyR3

Associated Targets

RYR1 Tclin Ryanodine receptor 1 0 Activities

Discover Target: RYR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RYR3 Tclin Ryanodine receptor 3 0 Activities

Discover Target: RYR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RYR2 Tclin Ryanodine receptor 2 0 Activities

Discover Target: RYR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(1R,2R,3S,6S,7S,9S,10R,11S,12R,13S,14R)-2,6,9,11,13,14-hexahydroxy-3,7,10-trimethyl-11-propan-2-yl-15-oxapentacyclo[7.5.1.01,6.07,13.010,14]pentadecan-12-yl] 1H-pyrrole-2-carboxylate
INCHI	InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19+,20-,21-,22+,23+,24+,25+/m0/s1
InChi Key	JJSYXNQGLHBRRK-SFEDZAPPSA-N
Canonical SMILES	CC1CCC2(C3(CC4(C5(C(C(C3(C5(C2(C1O)O4)O)O)OC(=O)C6=CC=CN6)(C(C)C)O)C)O)C)O
Isomeric SMILES	C[C@H]1CC[C@@]2([C@@]3(C[C@]4([C@@]5([C@]([C@H]([C@@]3([C@]5([C@]2([C@@H]1O)O4)O)O)OC(=O)C6=CC=CN6)(C(C)C)O)C)O)C)O
PubChem CID	11317883
Molecular Weight	493.56

Database links

Wikipedia	Ryanodine
CAS Registry No.	15662-33-6
PubChem CID	11317883
ChEBI	CHEBI:8925

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
A2417661	Certificate of Analysis	Jan 05, 2024	R275320
A2417662	Certificate of Analysis	Jan 05, 2024	R275320
F2308803	Certificate of Analysis	May 05, 2023	R275320
F2308804	Certificate of Analysis	May 05, 2023	R275320
A2305710	Certificate of Analysis	Dec 09, 2022	R275320

Chemical and Physical Properties

Solubility	Solubility：Soluble in water (slightly )；ethanol (16 mg/ml)；acetone；chloroform；ether；methanol (20 mg/ml）；and DMSO (>29 mg/ml).
Refractive Index	1.69 (Predicted)
Boil Point(°C)	714.16° C at 176 mmHg (Predicted)
Melt Point(°C)	219-220° C (dec.)

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H312:Harmful in contact with skin H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help.

References

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2. Grigoryan G et al.. (2014) Stress impairs synaptic plasticity in triple-transgenic Alzheimer's disease mice: rescue by ryanodine.. Neurodegener Dis, 13 (2-3): (135-8). [PMID:24008840]
3. Collin T et al.. (2009) Activation of metabotropic glutamate receptors induces periodic burst firing and concomitant cytosolic Ca2+ oscillations in cerebellar interneurons.. J Neurosci, 29 (29): (9281-91). [PMID:19625518]
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11. Westcott EB et al.. (2012) Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles.. J Physiol, 590 (Pt 8): (1849-69). [PMID:22331418]
12. McNally JM et al.. (2014) Functional ryanodine receptors in the membranes of neurohypophysial secretory granules.. J Gen Physiol, 143 (6): (693-702). [PMID:24863930]
13. Doengi M et al.. (2009) GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes.. Proc Natl Acad Sci U S A, 106 (41): (17570-5). [PMID:19805126]
14. Feng W et al.. (2010) Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1).. Biochem Pharmacol, 80 (4): (512-21). [PMID:20471964]
15. Westcott EB & Jackson WF. (2011) Heterogeneous function of ryanodine receptors, but not IP3 receptors, in hamster cremaster muscle feed arteries and arterioles.. Am J Physiol Heart Circ Physiol, 300 (5): (H1616-30). [PMID:21357503]
16. Ressmeyer AR et al.. (2010) Human airway contraction and formoterol-induced relaxation is determined by Ca2+ oscillations and Ca2+ sensitivity.. Am J Respir Cell Mol Biol, 43 (2): (179-91). [PMID:19767449]
17. Mukherjee S et al.. (2014) Insights into the gating mechanism of the ryanodine-modified human cardiac Ca2+-release channel (ryanodine receptor 2).. Mol Pharmacol, 86 (3): (318-29). [PMID:25002270]
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19. Ruiz A et al.. (2010) Intracellular Ca2+ release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes.. Cell Death Dis, 1 (e54). [PMID:21364659]
20. Luo R et al.. (2019) Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats.. FEBS J, 286 (21): (4356-4373). [PMID:31230413]
21. Sahu G et al.. (2019) Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability.. Cell Rep, 28 (9): (2427-2442.e6). [PMID:31461656]
22. King CM et al.. (2020) Local Resting Ca2+ Controls the Scale of Astroglial Ca2+ Signals.. Cell Rep, 30 (10): (3466-3477.e4). [PMID:32160550]
23. López-Sanjurjo CI et al.. (2013) Lysosomes shape Ins(1,4,5)P3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum.. J Cell Sci, 126 (Pt 1): (289-300). [PMID:23097044]
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28. Silswal N et al.. (2011) Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction.. Am J Physiol Heart Circ Physiol, 300 (6): (H2016-26). [PMID:21421826]
29. Wang M et al.. (2018) Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide.. Biomed Res Int, 2018 (2925985). [PMID:29511675]
30. Kur J et al.. (2014) Role of ion channels and subcellular Ca2+ signaling in arachidonic acid-induced dilation of pressurized retinal arterioles.. Invest Ophthalmol Vis Sci, 55 (5): (2893-902). [PMID:24699382]
31. Chen T et al.. (2019) ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury.. Neuroscience, 416 (268-280). [PMID:31425734]
32. Tykocki NR et al.. (2013) Ryanodine receptors are uncoupled from contraction in rat vena cava.. Cell Calcium, 53 (2): (112-9). [PMID:23177664]
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36. Garrity AG et al.. (2016) The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes.. Elife, 5 [PMID:27213518]

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Ryanodine - ≥98%, high purity , CAS No.15662-33-6, Activator of RyR1;Channel blocker of RyR1;Activator of RyR2;Channel blocker of RyR2;Activator of RyR3