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S 18986 - ≥98%(HPLC), high purity , CAS No.175340-20-2, Allosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4

Moligand™
≥98%(HPLC)

CAS#: 175340-20-2
Formula: C₁₀H₁₂N₂O₂S
Molecular Weight: 224.28
PubChem CID: 637863

Item Number

S288618

Grouped product items
SKU	Size	Availability	Price
S288618-10mg	10mg	In stock	$162.90
S288618-25mg	25mg	In stock	$365.90
S288618-100mg	100mg	In stock	$1,315.90

Positive allosteric modulator of AMPA receptors

View related series

GluA1 Allosteric modulator GluA2 Allosteric modulator GluA3 Allosteric modulator GluA4 Allosteric modulator

Basic Description

Synonyms	175340-20-2\|S 18986\|S-18986\|S18986\|(3aS)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide\|IA262432Y9\|(3aS)-2,3,3a,4-Tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine-5,5-dioxide\|UNII-IA262432Y9\|(3AS)-2,3,3A,4-TETRAHYDRO-1H-PYRROL
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Positive allosteric modulator of AMPA receptors. Exhibits cognitive enhancing properties in rodent behavioral models. Brain penetrant.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA4 Tclin Glutamate receptor 4 0 Activities

Discover Target: GRIA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIK1 Tclin Glutamate receptor ionotropic, kainate 1 0 Activities

Discover Target: GRIK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA2 Tclin Glutamate receptor 2 0 Activities

Discover Target: GRIA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA3 Tclin Glutamate receptor 3 0 Activities

Discover Target: GRIA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIA1 Tclin Glutamate receptor 1 0 Activities

Discover Target: GRIA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRIN1 Tclin Glutamate receptor ionotropic, NMDA 1 0 Activities

Discover Target: GRIN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3aS)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide
INCHI	InChI=1S/C10H12N2O2S/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11H,3,6-7H2/t10-/m1/s1
InChi Key	MNTIJYGEITVWHU-SNVBAGLBSA-N
Canonical SMILES	C1CC2NS(=O)(=O)C3=CC=CC=C3N2C1
Isomeric SMILES	C1C[C@@H]2NS(=O)(=O)C3=CC=CC=C3N2C1
PubChem CID	637863
Molecular Weight	224.28

CAS Registry No.

PubChem CID

Wikipedia

ChEMBL Ligand

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
F2306639	Certificate of Analysis	May 04, 2023	S288618
F2306640	Certificate of Analysis	May 04, 2023	S288618
F2306641	Certificate of Analysis	May 04, 2023	S288618
F2306642	Certificate of Analysis	May 04, 2023	S288618
F2306643	Certificate of Analysis	May 04, 2023	S288618
F2306644	Certificate of Analysis	May 04, 2023	S288618

References

1. Lockhart B, Iop F, Closier M, Lestage P. (2000) (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices.. Eur J Pharmacol, 401 (2): (145-53). [PMID:10924919]
2. Bernard K, Danober L, Thomas JY, Lebrun C, Muñoz C, Cordi A, Desos P, Lestage P, Morain P. (2010) DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptors pharmacological profile of a novel cognitive enhancer.. CNS Neurosci Ther, 16 (5): (e193-212). [PMID:21050420]

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