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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S646506-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $50.90 | |
S646506-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $80.90 | |
S646506-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $160.90 | |
S646506-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $250.90 | |
S646506-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $390.90 |
Synonyms | S-23|1010396-29-8|(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide|(2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide|CCTH-methylpropionamide|CHEMBL5122 |
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Specifications & Purity | 99% |
Storage Temp | Store at -20°C |
Shipped In | Dry ice |
Product Description | S-23 is an orally active selective androgen receptor modulator (SARM) with a K i of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats In Vitro S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED 50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague Dawley rats (in castrated male rats) Dosage: 0.01-3 mg Administration: S.c.; daily for 14 d Result: Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls. Form:Solid IC50& Target:Ki: 1.7 nM (Androgen receptor) |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide |
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INCHI | InChI=1S/C18H13ClF4N2O3/c1-17(27,9-28-12-4-5-14(19)15(20)7-12)16(26)25-11-3-2-10(8-24)13(6-11)18(21,22)23/h2-7,27H,9H2,1H3,(H,25,26)/t17-/m0/s1 |
InChi Key | SSFVOEAXHZGTRJ-KRWDZBQOSA-N |
Canonical SMILES | CC(COC1=CC(=C(C=C1)Cl)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O |
Isomeric SMILES | C[C@](COC1=CC(=C(C=C1)Cl)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O |
Alternate CAS | 1010396-29-8 |
PubChem CID | 24892822 |
MeSH Entry Terms | 1-phenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline;1-phenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride;1-phenyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, (+-)-isomer;6,7-dimethoxy-4-phenyl-1,2,3,4-tetrahydroisoquinolin |
Molecular Weight | 416.75 |
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Solubility | DMSO : 100 mg/mL (239.95 mM; Need ultrasonic) |
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