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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S654608-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $55.90 |
Specifications & Purity | 10mM in DMSO |
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Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | S-23 is an orally active selective androgen receptor modulator (SARM) with a K i of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats In Vitro S-23 induces AR-mediated transcriptional activation in CV-1 cells when used at a concentration of 10 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo By administration of S-23 to castrated animals, androgen-dependent organ weights increased in a dose-dependent manner. The ED 50 of S-23 in the prostate and levator ani muscle is 0.43 and 0.079 mg/d, respectively . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague Dawley rats (in castrated male rats) Dosage: 0.01-3 mg Administration: S.c.; daily for 14 d Result: Androgen-dependent organ weights increased in a dose-dependent manner. At a dose rate as low as 0.1 mg/d, S-23 is able to selectively maintain the weight of the levator ani muscle at the intact control level, whereas its effects on the prostate and seminal vesicles are lower than 30% of those observed in intact controls. IC50& Target:Ki: 1.7 nM (Androgen receptor) |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Canonical SMILES | CC(COC1=CC(=C(C=C1)Cl)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O |
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Molecular Weight | 416.75 |
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