Potent, selective mGlu 8a agonist (EC 50 = 31 nM). Displays >100-fold selectivity over mGlu 1-7 . Systemically active in vivo . Also available in simple stock solutions add 1 ml of water to get an exact, ready-to-use concentration.
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of mGlu 4 receptor;Agonist of mGlu 6 receptor;Agonist of mGlu 8 receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Beurrier C, Lopez S, Révy D, Selvam C, Goudet C, Lhérondel M, Gubellini P, Kerkerian-LeGoff L, Acher F, Pin JP et al.. (2009) Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.. FASEB J, 23 (10):(3619-28). [PMID:19525404]
2.Lopez S et al.. (2007) Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease.. J Neurosci, 27 (25):(6701-11). [PMID:17581957]
3.Gosnell HB et al.. (2011) mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner.. Neuropsychopharmacology, 36 (8):(1599-607). [PMID:21451497]
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