S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate - >98.0%(HPLC), high purity , CAS No.182004-65-5, Channel blocker of TRPC3;Channel blocker of TRPC5;Channel blocker of TRPC6
S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate - >98.0%(HPLC), high purity , CAS No.182004-65-5, Channel blocker of TRPC3;Channel blocker of TRPC5;Channel blocker of TRPC6
Channel blocker of TRPC3;Channel blocker of TRPC5;Channel blocker of TRPC6
Product Description
KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux.
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2.Wong RW et al.. (2018) Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.. Sci Rep, 8 (850). [PMID:29339801]
3.Sherkhane P & Kapfhammer JP. (2017) Chronic pharmacological blockade of the Na(+) /Ca(2+) exchanger modulates the growth and development of the Purkinje cell dendritic arbor in mouse cerebellar slice cultures.. Eur J Neurosci, [PMID:28715135]
4.Di Giuro CML et al.. (2017) Na +/Ca2+ exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca2+ via ER nanojunctions in vascular endothelial cells.. Pflugers Arch, 469 (10):(1287-1299). [PMID:28497275]
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D2102236