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S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate - >98.0%(HPLC), high purity , CAS No.182004-65-5, Channel blocker of TRPC3;Channel blocker of TRPC5;Channel blocker of TRPC6

Moligand™
≥98%(HPLC)

CAS#: 182004-65-5
Formula: C₁₆H₁₇N₃O₃S·CH₄O₃S
Molecular Weight: 427.49
MDL number: MFCD00952138
PubChem CID: 9823846

Item Number

S161158

Grouped product items
SKU	Size	Availability	Price
S161158-10mg	10mg	In stock	$109.90
S161158-50mg	50mg	In stock	$391.90
S161158-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$705.90

NCX inhibitor. TRPC blocker.

View related series

TRPC3 Channel blocker TRPC5 Channel blocker TRPC6 Channel blocker

Basic Description

Synonyms	182004-65-5\|KB-R7943 mesylate\|KB-R7943\|2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE\|KB-R7943 (mesylate)\|4-((4-Nitrobenzyl)oxy)phenethyl carbamimidothioate methanesulfonate\|KB-R 7943\|Carbamimidothioic acid, 2-[4-[(4-nitrophenyl)methoxy]pheny
Specifications & Purity	>98.0%(HPLC)
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of TRPC3;Channel blocker of TRPC5;Channel blocker of TRPC6
Product Description	KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 μM. KB-R7943 mesylate induces cancer cell death via activating the JNK pathway and blocking autophagic flux.

Associated Targets

TRPC3 Tchem Short transient receptor potential channel 3 0 Activities

Discover Target: TRPC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC5 Tchem Short transient receptor potential channel 5 1 Activities

Discover Target: TRPC5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC6 Tchem Short transient receptor potential channel 6 0 Activities

Discover Target: TRPC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	methanesulfonic acid;2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl carbamimidothioate
INCHI	InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
InChi Key	WGIKEBHIKKWJLG-UHFFFAOYSA-N
Canonical SMILES	CS(=O)(=O)O.C1=CC(=CC=C1CCSC(=N)N)OCC2=CC=C(C=C2)[N+](=O)[O-]
Isomeric SMILES	CS(=O)(=O)O.C1=CC(=CC=C1CCSC(=N)N)OCC2=CC=C(C=C2)[N+](=O)[O-]
PubChem CID	9823846
Molecular Weight	427.49
Reaxy-Rn	9099076

PubChem CID

9823846

CAS Registry No.

182004-65-5

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2 results found

Lot Number	Certificate Type	Date	Item
D2102236	Certificate of Analysis	Jan 02, 2024	S161158
D2102237	Certificate of Analysis	Jan 02, 2024	S161158

References

1. Wong RW et al.. (2020) An activator of G protein-coupled receptor and MEK1/2-ERK1/2 signaling inhibits HIV-1 replication by altering viral RNA processing.. PLoS Pathog, 16 (2): (e1008307). [PMID:32069328]
2. Wong RW et al.. (2018) Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.. Sci Rep, 8 (850). [PMID:29339801]
3. Sherkhane P & Kapfhammer JP. (2017) Chronic pharmacological blockade of the Na(+) /Ca(2+) exchanger modulates the growth and development of the Purkinje cell dendritic arbor in mouse cerebellar slice cultures.. Eur J Neurosci, [PMID:28715135]
4. Di Giuro CML et al.. (2017) Na +/Ca2+ exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca2+ via ER nanojunctions in vascular endothelial cells.. Pflugers Arch, 469 (10): (1287-1299). [PMID:28497275]

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