S-Gboxin - 96%, high purity , CAS No.2101317-21-7

  • ≥96%
Item Number
S412174
Grouped product items
SKUSizeAvailabilityPrice Qty
S412174-5mg
5mg
In stock
$882.90
S412174-10mg
10mg
In stock
$1,433.90
S412174-25mg
25mg
In stock
$2,265.90
S412174-50mg
50mg
In stock
$3,433.90
S412174-100mg
100mg
In stock
$5,243.90

OXPHOS Inhibitors

Basic Description

SynonymsAKOS037649109 | A936428 | 2101317-21-7 (iodide) | BS-16592 | 2101317-21-7 | EX-A2979 | [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 2-[3-methyl-2-[3-(trifluoromethyl)phenyl]benzimidazol-3-ium-1-yl]acetate;iodide | 3-(2-(((1R,2S,5R)-2-isopropyl-5-methylcy
Specifications & Purity≥96%
Biochemical and Physiological MechanismsS-Gboxin, a functional analogue of Gboxin, is an oxidative phosphorylation (OXPHOS) inhibitor which inhibits growth of mouse and human glioblastoma (GBM) with IC50 of 470 nM.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Information

S-Gboxin S-Gboxin, a functional analogue of Gboxin, is an oxidative phosphorylation (OXPHOS) inhibitor which inhibits growth of mouse and human glioblastoma (GBM) with IC50 of 470 nM.


Targets

OXPHOS ; GBM (Cell-based assay) ; 470 nM

Product Properties

ALogP4.587
Rotatable Bond7

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 2-[3-methyl-2-[3-(trifluoromethyl)phenyl]benzimidazol-3-ium-1-yl]acetate;iodide
INCHI InChI=1S/C27H32F3N2O2.HI/c1-17(2)21-13-12-18(3)14-24(21)34-25(33)16-32-23-11-6-5-10-22(23)31(4)26(32)19-8-7-9-20(15-19)27(28,29)30;/h5-11,15,17-18,21,24H,12-14,16H2,1-4H3;1H/q+1;/p-1/t18-,21+,24-;/m1./s1
InChi Key DCAJNAWCJSUZDG-DZJKTSMVSA-M
Canonical SMILES CC1CCC(C(C1)OC(=O)CN2C3=CC=CC=C3[N+](=C2C4=CC(=CC=C4)C(F)(F)F)C)C(C)C.[I-]
Isomeric SMILES C[C@@H]1CC[C@H]([C@@H](C1)OC(=O)CN2C3=CC=CC=C3[N+](=C2C4=CC(=CC=C4)C(F)(F)F)C)C(C)C.[I-]
PubChem CID 137628665
Molecular Weight 600.45

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
I2205214Certificate of AnalysisJun 07, 2022 S412174
I2205215Certificate of AnalysisJun 07, 2022 S412174
I2205217Certificate of AnalysisJun 07, 2022 S412174
I2205218Certificate of AnalysisJun 07, 2022 S412174
I2205219Certificate of AnalysisJun 07, 2022 S412174

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 100 mg/mL (166.54 mM); Ethanol: 100 mg/mL (166.54 mM); Water: ˂1 mg/mL
DMSO(mg / mL) Max Solubility100
DMSO(mM) Max Solubility166.541760346407
Water(mg / mL) Max Solubility˂1

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

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