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S-Lactoylglutathione - 90%, high purity , CAS No.54398-03-7

  • ≥90%
Item Number
L121369
Grouped product items
SKUSizeAvailabilityPrice Qty
L121369-5mg
5mg
In stock
$199.90
L121369-25mg
25mg
In stock
$749.90
View related series
polypeptide

Basic Description

SynonymsS-Pyruvylglutathione|JLC76XF39H|S-Pyruvoylglutathione|UNII-JLC76XF39H|(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-(2-oxopropanoylsulfanyl)propan-2-yl]amino]-5-oxopentanoic acid|Glycine, N-(S-(1,2-dioxopropyl)-N-L-gamma-glutamyl-L-cysteinyl)-|S-LA
Specifications & Purity90%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Names and Identifiers

IUPAC Name (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-(2-oxopropanoylsulfanyl)propan-2-yl]amino]-5-oxopentanoic acid
INCHI InChI=1S/C13H19N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h7-8H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/t7-,8-/m0/s1
InChi Key PPLZFKVEEDKGDM-YUMQZZPRSA-N
Canonical SMILES C[C@H](O)C(=O)SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O
Isomeric SMILES CC(=O)C(=O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N
WGK Germany 3
PubChem CID 20841753
Molecular Weight 379.39

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

6 results found

Lot NumberCertificate TypeDateItem
E2431284Certificate of AnalysisMay 21, 2024 L121369
E2431285Certificate of AnalysisMay 21, 2024 L121369
B2311914Certificate of AnalysisNov 18, 2022 L121369
B2311927Certificate of AnalysisNov 18, 2022 L121369
H2206894Certificate of AnalysisJul 30, 2022 L121369
H2206895Certificate of AnalysisJul 30, 2022 L121369

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3

Related Documents

References

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2. L G Edwards,A Adesida,P J Thornalley.  (1996-01-01)  Inhibition of human leukaemia 60 cell growth by S-D-lactoylglutathione in vitro. Mediation by metabolism to N-D-lactoylcysteine and induction of apoptosis..  Leukemia research,  20  ((1)): (17-26).  [PMID:8632674]
3. Nathan F Wenzel,Anne L Carenbauer,Mary Pam Pfiester,Oliver Schilling,Wolfram Meyer-Klaucke,Christopher A Makaroff,Michael W Crowder.  (2004-04-07)  The binding of iron and zinc to glyoxalase II occurs exclusively as di-metal centers and is unique within the metallo-beta-lactamase family..  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry,  ((4)): (429-438).  [PMID:15067523]
4. A Klimes,M J Neumann,S J Grant,K F Dobinson.  (2006-11-18)  Characterization of the glyoxalase I gene from the vascular wilt fungus Verticillium dahliae..  Canadian journal of microbiology,  52  ((9)): (816-822).  [PMID:17110973]
5. Pattraranee Limphong,Nicole E Adams,Matthew F Rouhier,Ross M McKinney,Melissa Naylor,Brian Bennett,Christopher A Makaroff,Michael W Crowder.  (2010-08-19)  Converting GLX2-1 into an active glyoxalase II..  Biochemistry,  49  ((37)): (8228-8236).  [PMID:20715794]
6. E M Choi,K S Suh,S Y Rhee,Y S Kim.  (2014-03-19)  Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis..  Free radical research,  48  ((7)): (729-739).  [PMID:24628445]
7. Sarah Martin,Kaushik Desai.  (2019-10-28)  The effects of oral arginine on its metabolic pathways in Sprague-Dawley rats..  The British journal of nutrition,  123  ((2)): (135-148).  [PMID:31647043]
8. Saad Mustafa,Mohammad Mobashir.  (2019-12-08)  LC-MS and docking profiling reveals potential difference between the pure and crude fucoidan metabolites..  International journal of biological macromolecules,  143  (11-29).  [PMID:31811847]
9. Ørjan Samuelsen,Ove Alexander Høgmoen Åstrand,Christopher Fröhlich,Adam Heikal,Susann Skagseth,Trine Josefine Olsen Carlsen,Hanna-Kirsti S Leiros,Annette Bayer,Christian Schnaars,Geir Kildahl-Andersen,Silje Lauksund,Sarah Finke,Sandra Huber,Tor Gjøen,Adriana Magalhaes Santos Andresen,Ole Andreas Økstad,Pål Rongved.  (2020-03-18)  ZN148 Is a Modular Synthetic Metallo-β-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo..  Antimicrobial agents and chemotherapy,  64  ((6)):   [PMID:32179522]
10. Ananda Mustafiz,Khirod K Sahoo,Sneh L Singla-Pareek,Sudhir K Sopory.  (2010-04-14)  Metabolic engineering of glyoxalase pathway for enhancing stress tolerance in plants..  Methods in molecular biology (Clifton, N.J.),  639  (95-118).  [PMID:20387042]
11. Ertan Ozyamak,Susan S Black,Claire A Walker,Morag J Maclean,Wendy Bartlett,Samantha Miller,Ian R Booth.  (2010-12-15)  The critical role of S-lactoylglutathione formation during methylglyoxal detoxification in Escherichia coli..  Molecular microbiology,  78  ((6)): (1577-1590).  [PMID:21143325]
12. Kwang Sik Suh,Suk Chon,Eun Mi Choi.  (2018-05-25)  Protective effects of piceatannol on methylglyoxal-induced cytotoxicity in MC3T3-E1 osteoblastic cells..  Free radical research,  52  ((6)): (712-723).  [PMID:29792365]
13. Valeria Cordone,Alessandra Pecorelli,Mascia Benedusi,Silvano Santini,Stefano Falone,Joussef Hayek,Fernanda Amicarelli,Giuseppe Valacchi.  (2019-02-20)  Antiglycative Activity and RAGE Expression in Rett Syndrome..  Cells,  ((2)):   [PMID:30781346]
14. Tobias Baumann,Andreas Dunkel,Christian Schmid,Sabine Schmitt,Michael Hiltensperger,Kerstin Lohr,Vibor Laketa,Sainitin Donakonda,Uwe Ahting,Bettina Lorenz-Depiereux,Jan E Heil,Johann Schredelseker,Luca Simeoni,Caroline Fecher,Nina Körber,Tanja Bauer,Norbert Hüser,Daniel Hartmann,Melanie Laschinger,Kilian Eyerich,Stefanie Eyerich,Martina Anton,Matthew Streeter,Tina Wang,Burkhart Schraven,David Spiegel,Farhah Assaad,Thomas Misgeld,Hans Zischka,Peter J Murray,Annkristin Heine,Mathias Heikenwälder,Thomas Korn,Corinna Dawid,Thomas Hofmann,Percy A Knolle,Bastian Höchst.  (2020-04-25)  Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal..  Nature immunology,  21  ((5)): (555-566).  [PMID:32327756]

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