(S)-Mephenytoin - ≥98%, high purity , CAS No.70989-04-7

Item Number

M335343

• Synonyms: (S)-Mephenytoin|70989-04-7|S-Mephenytoin|(S)-(+)-Mephenytoin|(5s)-5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione|Mephenytoin, (+)-|(S)-5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione|Mephenytoin, D-|(+)-Mephenytoin|(+)-Mesantoin|(+)-S-Mephenytoin|(5S)-
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: CYP2B6 & CYP2C19 substrate. Methenytoin isomer. Anticonvulsant; antiepileptic.This product is only used for scientific research.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Note: (S)-Mephenytoin is slightly soluble in DMSO, Ethanol and Methanol.

Product Description

(S)-Mephenytoin is a hydantoin small molecule, originally discovered and implemented for its anticonvulsant effects. Individuals present a variable ability to perform hydroxylation of (S)-Mephenytoin at the 4'-position associated with polymorphism in CYP2C19, an oxidase in the cytochrome P-450 system. The poor metabolizer phenotype, those incapable of metabolizing (S)-Mephenytoin by 4'-hydroxylation, also show a reduced ability to clear other pharmaceuticals and xenobiotics, and this (S)-Mephenytoin metabolism experiment has been used to explore the implications of this common phenotypic condition in drug design and toxicity expectations. (S)-Mephenytoin is a substrate of CYP2B6 and CYP2C19.

Application：

S-Mephenytoin has been used as a CYP2C19 substrate for the analysis of cytochrome P450 metabolism. S-Mephenytoin has also been used as probe substrates for LC/MS-based analysis of relative activity factor (RAF).