| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| S463452-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,273.90 |
| Specifications & Purity | ≥95% |
|---|---|
| Legal Information | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | Description Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
| IUPAC Name | (2S,4R)-1-[(2S)-3,3-dimethyl-2-[3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoylamino]butanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
|---|---|
| INCHI | InChI=1S/C32H44N4O7S/c1-6-12-41-14-16-43-17-15-42-13-11-27(38)35-29(32(3,4)5)31(40)36-20-25(37)18-26(36)30(39)33-19-23-7-9-24(10-8-23)28-22(2)34-21-44-28/h1,7-10,21,25-26,29,37H,11-20H2,2-5H3,(H,33,39)(H,35,38)/t25-,26+,29-/m1/s1 |
| InChi Key | VAUAWSOCVFFOPH-UWPQIUOOSA-N |
| Canonical SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCOCCOCC#C)O |
| PubChem CID | 145710072 |
| Molecular Weight | 628.78 |
Enter Lot Number to search for COA:
| Flash Point(°F) | Not applicable |
|---|---|
| Flash Point(°C) | Not applicable |
| RIDADR | NONH for all modes of transport |
|---|
Starting at $1,254.90
Starting at $86.90
Starting at $1,553.90
Starting at $216.90
Starting at $1,257.90
Starting at $1,257.90
Starting at $1,257.90
Starting at $1,273.90
Starting at $1,273.90
Starting at $1,198.90
Starting at $543.90
Starting at $1,417.90
Starting at $1,339.90
Starting at $1,218.90
Starting at $335.90
Starting at $335.90
Starting at $216.90
Starting at $891.90
Starting at $1,273.90
Starting at $1,198.90
