| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| S463414-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,198.90 |
| Specifications & Purity | ≥95% |
|---|---|
| Legal Information | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| Storage Temp | Store at 2-8°C |
| Shipped In | Wet ice |
| Product Description | Description Protein degrader builiding block (S,R,S)-AHPC-PEG6-Azide enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant azide for click chemistry with an alkyne on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
| IUPAC Name | (2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
|---|---|
| INCHI | InChI=1S/C36H55N7O10S/c1-26-32(54-25-39-26)28-7-5-27(6-8-28)22-38-34(46)30-21-29(44)23-43(30)35(47)33(36(2,3)4)41-31(45)24-53-20-19-52-18-17-51-16-15-50-14-13-49-12-11-48-10-9-40-42-37/h5-8,25,29-30,33,44H,9-24H2,1-4H3,(H,38,46)(H,41,45)/t29-,30+,33-/m1/s1 |
| InChi Key | AJSBEOXYBAZQFR-YLJHYDRVSA-N |
| Canonical SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)COCCOCCOCCOCCOCCOCCN=[N+]=[N-])O |
| PubChem CID | 126620085 |
| Molecular Weight | 777.93 |
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| Flash Point(°F) | Not applicable |
|---|---|
| Flash Point(°C) | Not applicable |
| 1. Momar Toure, Craig M Crews,. (2016-01-13) Small-Molecule PROTACS: New Approaches to Protein Degradation.. Angewandte Chemie (International ed. in English), 55 ((6)): ( 1966-1973 ). [PMID:26756721] |
