(S,R,S)-AHPC-PEG₂-butyl alkyne - ≥95%, high purity

Item Number

S463549

• Specifications & Purity: ≥95%
• Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice

Product Description

Description

Protein degrader builiding block (S,R,S)-AHPC-PEG2-butyl alkyne enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.