(S,R,S)-AHPC-PEG₂-butyl amine hydrochloride

Item Number

S487815

• Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice

Product Description

Description

Protein degrader builiding block (S,R,S)-AHPC-PEG2-butyl amine (HCl salt) enables the synthesis of molecules fortargeted protein degradationandPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.