Reaction type Hydrogenation, Asymmetric Reactions, Asymmetric Hydrogenation, Transfer Hydrogenation
Chemical properties
Chemical formula
C54H46Cl2P2Ru
Empirical formula
[RuCl(p-cymene)(S)-BINAP)]Cl
Molecular weight
928.88
Metal
Ru
Theoretical metal content
11
Physical state
powder
Color
red orange
Applications & references
Synthesis of (R)- or (S)-4-halo-3-hydroxybuyrate ester by asymmetric hydrogenation of 4-halo-3-oxobutanoate ester; this reaction can be applied in the Producteion of L-carnitine.
Reference: EP2386536
Enantioselective hydrogenation of functionalized ketones.
Reference: EP0366390
Asymmetric hydrogenation of halogenated acetophenones to enantiomerically pure halogenated phenyl ethanol derivatives.
Reference: Cat. Lett. 1996, 41, 111 (DOI: 10.1007/BF00811721)
Highly enantioselective catalytic hydrogenation of methyl-N-tertbutyl-3-oxoglutarate as a key step in the total synthesis of rovastatin.
Reference: Tetrah. Lett. 2008, 49, 4836 (DOI: 10.1016/j.tetlet.2008.06.018)
Enantioselective hydrogenation of 4-(hydroxymethyl)furan-2(5H)-one derivatives.