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S-Ruxolitinib (INCB018424) - 98%, high purity , CAS No.941685-37-6, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2

Moligand™
≥98%

CAS#: 941685-37-6
Formula: C₁₇H₁₈N₆
Molecular Weight: 306.37
PubChem CID: 50878566

Item Number

S129613

Grouped product items
SKU	Size	Availability	Price
S129613-1mg	1mg	In stock	$17.90
S129613-5mg	5mg	In stock	$70.90
S129613-10mg	10mg	In stock	$82.90
S129613-25mg	25mg	In stock	$112.90
S129613-50mg	50mg	In stock	$141.90
S129613-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$189.90

View related series

Janus kinase 1 Inhibitor Janus kinase 2 Inhibitor Janus kinase 3 Inhibitor tyrosine kinase 2 Inhibitor

Basic Description

Synonyms	S-Ruxolitinib\|941685-37-6\|S-Ruxolitinib (INCB018424)\|Ruxolitinib (S enantiomer)\|Ruxolitinib S enantiomer\|(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile\|CHEMBL1287854\|(R)-ruxolitinib\|(3S)-3-cyclopentyl-3-[4-(7H-pyr
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3;Inhibitor of tyrosine kinase 2

Associated Targets

TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 2 Activities

Discover Target: TYK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK3 Tclin Tyrosine-protein kinase JAK3 2 Activities

Discover Target: JAK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK1 Tclin Tyrosine-protein kinase JAK1 1 Activities

Discover Target: JAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 2 Activities

Discover Target: JAK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3S)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
INCHI	InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m0/s1
InChi Key	HFNKQEVNSGCOJV-HNNXBMFYSA-N
Canonical SMILES	C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
Isomeric SMILES	C1CCC(C1)[C@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
PubChem CID	50878566
Molecular Weight	306.37

CAS Registry No.

Wikipedia

DiscoveRx TREEspot

PubChem CID

ChEMBL Ligand

RCSB PDB Ligand

PEP

Reactome Reaction

R-HSA-9678737, R-HSA-9678935, R-HSA-9678561, R-HSA-9679028

Reactome Drug

R-ALL-9678786

DrugCentral Ligand

4190

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

6 results found

Lot Number	Certificate Type	Date	Item
B2207101	Certificate of Analysis	Nov 14, 2023	S129613
B2207102	Certificate of Analysis	Nov 14, 2023	S129613
B2207103	Certificate of Analysis	Nov 14, 2023	S129613
B2207109	Certificate of Analysis	Nov 14, 2023	S129613
B2207388	Certificate of Analysis	Nov 14, 2023	S129613
B2207391	Certificate of Analysis	Nov 14, 2023	S129613

Solubility

DMSO 61 mg/mL Water 5 mg/mL Ethanol 61 mg/mL

Melt Point(°C)

138-143ºC

References

1. Hanan EJ, van Abbema A, Barrett K, Blair WS, Blaney J, Chang C, Eigenbrot C, Flynn S, Gibbons P, Hurley CA et al.. (2012) Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.. J Med Chem, 55 (22): (10090-107). [PMID:23061660]
2. Mackay-Wiggan J, Jabbari A, Nguyen N, Cerise JE, Clark C, Ulerio G, Furniss M, Vaughan R, Christiano AM, Clynes R. (2016) Oral ruxolitinib induces hair regrowth in patients with moderate-to-severe alopecia areata.. JCI Insight, 1 (15): (e89790). [PMID:27699253]
3. Xing L, Dai Z, Jabbari A, Cerise JE, Higgins CA, Gong W, de Jong A, Harel S, DeStefano GM, Rothman L et al.. (2014) Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.. Nat Med, 20 (9): (1043-9). [PMID:25129481]

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