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SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
T275482-1mg | 1mg | In stock | $216.90 | |
T275482-5mg | 5mg | In stock | $761.90 |
TNF-α processing inhibitor
Specifications & Purity | ≥95% |
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Biochemical and Physiological Mechanisms | Stable, selective inhibitor of TNF-α processing (IC 50 = ~100 nM).\xa0 Inhibits TACE (P< 0.01) and other metalloproteases in vivo . |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. |
Product Description | Product Describtion: (S,S)-TAPI-1 is an isomer of TAPI-1. TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor. |
Pubchem Sid | 504764919 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504764919 |
IUPAC Name | N-[(2S)-1-[[(2S)-1-(2-aminoethylamino)-1-oxopropan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide |
INCHI | InChI=1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21?,22-/m0/s1 |
InChi Key | AWNBSWDIOCXWJW-OWHMDLSXSA-N |
Canonical SMILES | CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NCCN |
Isomeric SMILES | C[C@@H](C(=O)NCCN)NC(=O)[C@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)C(CC(C)C)CC(=O)NO |
PubChem CID | 9827273 |
Molecular Weight | 499.6 |
Find and download the COA for your product by matching the lot number on the packaging.
4 results found
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
Certificate of Analysis | Jun 12, 2024 | T275482 | |
Certificate of Analysis | Apr 12, 2024 | T275482 | |
Certificate of Analysis | Apr 07, 2024 | T275482 | |
Certificate of Analysis | Apr 07, 2024 | T275482 |
Solubility | Soluble in DMSO to 10 mM |
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Starting at $241.90
1. Sisto M et al.. (2015) The metalloproteinase ADAM17 and the epidermal growth factor receptor (EGFR) signaling drive the inflammatory epithelial response in Sjögren's syndrome.. Clin Exp Med, 15 (2): (215-25). [PMID:24664458] |
2. Li X et al.. (2014) [Effects of tumor necrosis factor-a converting enzyme on mucous hypersecretion in inflammatory airway].. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 39 (12): (1228-32). [PMID:25544160] |
3. Chatterjee A et al.. (2020) Functions of interleukin-6 in ovulation of female climbing perch, Anabas testudineus.. Anim Reprod Sci, 219 (106528). [PMID:32828404] |
4. Yamamoto K et al.. (2014) Pericellular proteolysis by matrix metalloproteinase-7 is differentially modulated by cholesterol sulfate, sulfatide, and cardiolipin.. FEBS J, 281 (15): (3346-56). [PMID:24903600] |
5. Sun X et al.. (2015) The activation of EGFR promotes myocardial tumor necrosis factor-a production and cardiac failure in endotoxemia.. Oncotarget, 6 (34): (35478-95). [PMID:26486084] |
6. Zhang Y et al.. (2014) The human Cathelicidin LL-37 induces MUC5AC mucin production by airway epithelial cells via TACE-TGF-a-EGFR pathway.. Exp Lung Res, 40 (7): (333-42). [PMID:24901072] |