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Saccharin - 98%, high purity , CAS No.81-07-2, Agonist of TAS2R31;Agonist of TAS2R43

  • Moligand™
  • ≥98%
Item Number
S112429
Grouped product items
SKUSizeAvailabilityPrice Qty
S112429-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$16.90
S112429-100g
100g
In stock
$58.90
S112429-500g
500g
In stock
$261.90
View related series
TAS2R31 Agonist TAS2R43 Agonist

Basic Description

Synonymssaccharin|81-07-2|o-Benzoic sulfimide|o-Sulfobenzimide|Saccharine|Saccharimide|Benzosulfimide|Benzoic sulfimide|Garantose|o-Benzosulfimide|Benzosulphimide|Saccharinol|Saccharinose|Gluside|Benzosulfinide|Hermesetas|Saccharol|Glucid|Sweeta|Benzoic sulphimid
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsA non-nutritive sweetener and a pharmaceutic aid (flavor). Saccharin was previously listed as a reasonably anticipated human carcinogen but was delisted because the cancer data are not sufficient to meet the current criteria for this listing.
Storage TempArgon charged
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of TAS2R31;Agonist of TAS2R43
Product Description

Usually used in high performance liquid chromatographic method for the simultaneous separation and determination of acesulfame potassium, saccharine and aspartame;and also used in sweet preference test of rats.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FBP1 Tchem Fructose-1,6-bisphosphatase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA5A Tclin Carbonic anhydrase 5A, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

VDR Tclin Vitamin D3 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TAS1R3 Tbio Taste receptor type 1 member 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TAS2R43 Tchem Taste receptor type 2 member 43 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

USP2 Tbio Ubiquitin carboxyl-terminal hydrolase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LMNA Tbio Prelamin-A/C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA5B Tclin Carbonic anhydrase 5B, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA6 Tclin Carbonic anhydrase 6 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA1 Tclin Carbonic anhydrase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA3 Tclin Carbonic anhydrase 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA2 Tclin Carbonic anhydrase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA4 Tclin Carbonic anhydrase 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA12 Tclin Carbonic anhydrase 12 8 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA14 Tclin Carbonic anhydrase 14 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA9 Tclin Carbonic anhydrase 9 10 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA7 Tclin Carbonic anhydrase 7 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PRMT1 Tchem Protein arginine N-methyltransferase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APP Tclin Amyloid-beta A4 protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TAS2R31 Tchem Taste receptor type 2 member 31 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

THRB Tclin Thyroid hormone receptor beta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDM4A Tchem Lysine-specific demethylase 4A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1,1-dioxo-1,2-benzothiazol-3-one
INCHI InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
InChi Key CVHZOJJKTDOEJC-UHFFFAOYSA-N
Canonical SMILES C1=CC=C2C(=C1)C(=O)NS2(=O)=O
Isomeric SMILES C1=CC=C2C(=C1)C(=O)NS2(=O)=O
WGK Germany 2
RTECS DE4200000
Alternate CAS 128-44-9,6381-61-9,81-07-2
PubChem CID 5143
NSC Number 5349
MeSH Entry Terms Calcium, Saccharin;Saccharin;Saccharin Calcium;Saccharin Sodium
Molecular Weight 183.18
Beilstein 6888
Reaxy-Rn 6888

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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13 results found

Lot NumberCertificate TypeDateItem
L2322238Certificate of AnalysisDec 12, 2023 S112429
L2322247Certificate of AnalysisDec 12, 2023 S112429
L2322248Certificate of AnalysisDec 12, 2023 S112429
L2322249Certificate of AnalysisDec 12, 2023 S112429
C2313028Certificate of AnalysisFeb 16, 2023 S112429
C2313033Certificate of AnalysisFeb 16, 2023 S112429
C2313034Certificate of AnalysisFeb 16, 2023 S112429
C2313035Certificate of AnalysisFeb 16, 2023 S112429
J2330038Certificate of AnalysisFeb 16, 2023 S112429
C2228007Certificate of AnalysisFeb 23, 2022 S112429
C2228010Certificate of AnalysisFeb 23, 2022 S112429
C2228017Certificate of AnalysisFeb 23, 2022 S112429
C2228041Certificate of AnalysisFeb 23, 2022 S112429

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Chemical and Physical Properties

SolubilitySoluble in water (3.3 g/L at 20°C).
SensitivityMoisture sensitive.
Melt Point(°C)229°C

Safety and Hazards(GHS)

WGK Germany 2
RTECS DE4200000
Reaxy-Rn 6888
Merck Index 8311

Related Documents

References

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56. Jean-Christophe Delpech,Nicolas Saucisse,Shauna L Parkes,Chloe Lacabanne,Agnes Aubert,Fabrice Casenave,Etienne Coutureau,Nathalie Sans,Sophie Layé,Guillaume Ferreira,Agnes Nadjar.  (2015-02-24)  Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission..  The Journal of neuroscience : the official journal of the Society for Neuroscience,  35  ((7)): (3022-3033).  [PMID:25698740]
57. William J Horton,Hannah J Gissel,Jennifer E Saboy,Kenneth P Wright,Jerry A Stitzel.  (2015-02-24)  Melatonin administration alters nicotine preference consumption via signaling through high-affinity melatonin receptors..  Psychopharmacology,  232  ((14)): (2519-2530).  [PMID:25704105]
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