Sacubitril/valsartan (LCZ696) - 10mM in DMSO, high purity , CAS No.936623-90-4(DMSO)

  • 10mM in DMSO
Item Number
S408027
Grouped product items
SKUSizeAvailabilityPrice Qty
S408027-1ml
1ml
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$84.90

Neprilysin Inhibitors

Basic Description

Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsSacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Information

Sacubitril/valsartan (LCZ696) Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and h
In vitro


In vivo

In double-transgenic rats overexpressing human renin and angiotensinogen and plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) induces a dose-dependent and long-lasting reduction in mean arterial pressure (MAP), and stimulates a rapid and dose-dependent augmentation of plasma ANP immunoreactivity. In rat myocardial infarction (MI) model, LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy.
Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

Names and Identifiers

Canonical SMILES [Na+].[Na+].[Na+].CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NN=N[NH]3)C(C(C)C)C(O)=O.CCOC(=O)C(C)CC(CC4=CC=C(C=C4)C5=CC=CC=C5)NC(=O)CCC(O)=O
Molecular Weight 915.98

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Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro      

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Solution Calculators