Sacubitril/valsartan (LCZ696) - 99%, high purity , CAS No.936623-90-4

  • ≥99%
Item Number
V413811
Grouped product items
SKUSizeAvailabilityPrice Qty
V413811-100mg
100mg
In stock
$59.90
V413811-250mg
250mg
In stock
$102.90
V413811-1g
1g
In stock
$285.90
V413811-5g
5g
In stock
$999.90

Neprilysin Inhibitors

Basic Description

SynonymsSacubitril mixture with Valsartan | Valsartan | Sacubitril | LCZ696
Specifications & Purity≥99%
Biochemical and Physiological MechanismsSacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
Product Description

Information

Sacubitril/valsartan (LCZ696) Sacubitril/valsartan (LCZ696, Sacubitril, Valsartan), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.


Targets

RAAS


In vivo

In double-transgenic rats overexpressing human renin and angiotensinogen and plasma atrial natriuretic peptide immunoreactivity, LCZ696 (60 mg/kg p.o.) induces a dose-dependent and long-lasting reduction in mean arterial pressure (MAP), and stimulates a rapid and dose-dependent augmentation of plasma ANP immunoreactivity. In rat myocardial infarction (MI) model, LCZ696 (68 mg/kg p.o.) attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy.

Names and Identifiers

Molecular Weight 915.98

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
D2419033Certificate of AnalysisApr 07, 2024 V413811
D2419034Certificate of AnalysisApr 07, 2024 V413811
B2318336Certificate of AnalysisFeb 04, 2023 V413811
B2318338Certificate of AnalysisFeb 04, 2023 V413811
B2318339Certificate of AnalysisFeb 04, 2023 V413811
B2318341Certificate of AnalysisFeb 04, 2023 V413811

Chemical and Physical Properties

SolubilitySolubility (25°C) In vitro DMSO: 100 mg/mL warmed with 50ºC Water: bath (109.17 mM); Water: 100 mg/mL warmed with 50ºC Water: bath (109.17 mM); Ethanol: 100 mg/mL warmed with 50ºC Water: bath (109.17 mM);
SensitivityLight sensitive;Moisture Sensitive

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Solution Calculators