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Safinamide - ≥98%, high purity , Monoamine oxidase B inhibitor, CAS No.133865-89-1, Monoamine oxidase B inhibitor

Moligand™
≥98%

CAS#: 133865-89-1
Formula: C₁₇H₁₉FN₂O₂
Molecular Weight: 302.34
PubChem CID: 131682

Item Number

S125282

Grouped product items
SKU	Size	Availability	Price
S125282-10mg	10mg	In stock	$19.90
S125282-50mg	50mg	In stock	$66.90
S125282-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$232.90
S125282-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$659.90
S125282-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,289.90

View related series

Monoamine oxidase B Inhibitor

Basic Description

Synonyms	Safinamide\|133865-89-1\|(S)-2-((4-((3-Fluorobenzyl)oxy)benzyl)amino)propanamide\|(2S)-2-[[4-[(3-Fluorophenyl)methoxy]phenyl]methylamino]propanamide\|Xadago\|EMD 1195686\|EMD-1195686\|UNII-90ENL74SIG\|90ENL74SIG\|Fce-26743\|2-(4-(3-Fluorobenzyloxy)benzylamino)propi
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, Safinamide is voltage-dependent sodium and calcium channel blocker. Safinamide appears to bind to th
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Monoamine oxidase B inhibitor
Note	10mg卖完停产，不再备货
Product Description	Safinamide (EMD 1195686; FCE 26743) selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A.

Names and Identifiers

IUPAC Name	(2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide
INCHI	InChI=1S/C17H19FN2O2/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14/h2-9,12,20H,10-11H2,1H3,(H2,19,21)/t12-/m0/s1
InChi Key	NEMGRZFTLSKBAP-LBPRGKRZSA-N
Canonical SMILES	CC(C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F
Isomeric SMILES	C[C@@H](C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F
PubChem CID	131682
Molecular Weight	302.34

PubChem CID

CAS Registry No.

ChEMBL Ligand

Wikipedia

DrugCentral Ligand

Certificates

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Lot Number	Certificate Type	Date	Item
E1529132	Certificate of Analysis	Jan 11, 2023	S125282

Solubility

DMSO

Sensitivity

heat sensitive

Melt Point(°C)

212°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS09, GHS05
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H318:Causes serious eye damage H400:Very toxic to aquatic life
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help.

References

1. Caccia C, Maj R, Calabresi M, Maestroni S, Faravelli L, Curatolo L, Salvati P, Fariello RG. (2006) Safinamide: from molecular targets to a new anti-Parkinson drug.. Neurology, 67 (7 Suppl 2): (S18-23). [PMID:17030736]
2. Binda C, Wang J, Pisani L, Caccia C, Carotti A, Salvati P, Edmondson DE, Mattevi A. (2007) Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs.. J Med Chem, 50 (23): (5848-52). [PMID:17915852]

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Safinamide - ≥98%, high purity , Monoamine oxidase B inhibitor, CAS No.133865-89-1, Monoamine oxidase B inhibitor

Basic Description

Product Properties

Associated Targets

MAOB Tclin Amine oxidase [flavin-containing] B 44 Activities

Names and Identifiers

Database links