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Salmeterol - ≥98%, high purity , CAS No.89365-50-4, Agonist of β 2-adrenoceptor
a potent and selective β2-AR agonist
Basic Description Synonyms Salmeterol|89365-50-4|Serevent|Astmerole|Aeromax|Salmeterolum [Latin]|Salmeterolum|GR 33343X|2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol|SALMATEROL|SN408D|HSDB 7315|UNII-2I4BC502BT|GR 33343 X|2I4BC502BT|DTXSID6023571|GR-333 Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type AGONIST Mechanism of action Agonist of β 2-adrenoceptor Product Description Salmeterol is a potent and selective β2-AR adrenoceptor agonist (EC|50|= 5.3 nM) that displays bronchodilator actions. Unlike other β2-AR agonists, Salmeterol binds to exo-site domain of β2-AR receptors, producing a slow onset of action and prolonged activation.
Product Properties pKa pKₐ: 9.99 (Predicted), pKₐ: 9.26 (Predicted) Ki Data β2-AR: Ki= 0.39 nM (human); β1-AR: Ki= 801 nM (human)
Names and Identifiers IUPAC Name 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol INCHI InChI=1S/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2 InChi Key GIIZNNXWQWCKIB-UHFFFAOYSA-N Canonical SMILES C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O Isomeric SMILES C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O RTECS CZ6457000 PubChem CID 5152 Molecular Weight 415.57
Chemical and Physical Properties Solubility Soluble in ethanol (50 mM), and DMSO (100 mM). Refractive Index n20D1.57 (Predicted) Boil Point(°C) ~603.0° C at 760 mmHg (Predicted) Melt Point(°C) 243.54° C (Predicted)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H412: Harmful to aquatic life with long lasting effects
H302: Harmful if swallowed
H317: May cause an allergic skin reaction
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P272: Contaminated work clothing should not be allowed out of the workplace.
P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
P330: Rinse mouth.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P301+P317: IF SWALLOWED: Get medical help.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
RTECS CZ6457000
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