Sanggenon G , CAS No.85698-31-3

Item Number
S647929
Grouped product items
SKUSizeAvailabilityPrice Qty
S647929-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$430.90
S647929-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,300.90

Flavonoids Flavonones

Basic Description

Biochemical and Physiological MechanismsSanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP) . Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase activation.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Sanggenon G is a cell-permeable and potent inhibitor of X-linked inhibitor of apoptosis protein (XIAP) . Sanggenon G binds specifically to the BIR3 domain of XIAP with a binding affinity of 34.26 μM. Sanggenon G enhances caspase activation

In Vitro

Sanggenon G (14.4 μM, 24 h) enhances caspase-8, -3 and -9 cleavage, displaces caspase-9 from XIAP and sensitizes Molt3/XIAP cells to Etoposide (HY-13629)-induced apoptosis. Sanggenon G not only sensitizes the XIAP-overexpressing leukemia cell line Molt3/XIAP to Etoposide (HY-13629) treatment but also different neuroblastoma cell lines endogenously expressing high XIAP levels. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Caspase-3 Caspase-8 Caspase-9

Names and Identifiers

Canonical SMILES O=C1C[C@@H](C2=CC=C(O)C=C2O)OC3=CC(O)=C([C@H]4C=C(CC/C=C(C)/C)C[C@@H](C5=CC=C(O)C=C5O)[C@@H]4C(C6=CC=C(O)C=C6O)=O)C(O)=C13
Molecular Weight 694.72

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