SB-408124 Hydrochloride - 98%, high purity , CAS No.1431697-90-3

  • ≥98%
Item Number
S648569
Grouped product items
SKUSizeAvailabilityPrice Qty
S648569-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$72.90
S648569-10mg
10mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$108.90
S648569-50mg
50mg
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$336.90
S648569-100mg
100mg
Available within 8-12 weeks(?)
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$600.90

Basic Description

SynonymsCS-1073 | N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]urea hydrochloride | F84881 | MS-26581 | SB-408124 HCl | SB-408124 Hydrochloride | AKOS030526528 | SB-408124 (Hydrochloride) | 1-(6,8-difluoro-2-methylquinolin-4-yl)-3-[4-(dimeth
Specifications & Purity98%
Storage TempStore at 2-8°C,Desiccated
Shipped InWet ice
Product Description

SB-408124 Hydrochloride is a selective non-peptide orexin receptor 1 (OX1) receptor antagonist with K i s of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 Hydrochloride exhibits 50-fold selectivity over OX2 receptor

In Vitro

Primary neuronal cultures from the hypothalamus of newborn SD rats are incubated with orexin A (1 µM), orexin A (1 µM) together with SB-408124 (100 µM) for 6 h. Orexin A-induced increases in arginine Vasotocin (AVP) mRNA levels (2.7-fold) are attenuated by SB-408124 (1.2-fold). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB-408124 reduces anxiety after psychotraumatic exposure. Predator induces acute psychotraumatic exposure decrease corticoliberin level in the rat's amygdala. Intranasal administration of SB-408124 restores it closely to normal and has an anxiolytic effect on animal behaviour. Bilateral paraventricular nucleus microinjection of SB-408124 (30 pmol/50 nL per side) results in a greater reduction in mean arterial pressure (MAP) in high-salt intake (-16 mmHg) compared with NS-fed (-4 mmHg) anesthetized Dahl salt-sensitive rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:OX 1 Receptor 57 nM (Ki, in whole cell ) OX 1 Receptor 27 nM (Ki, in cell membrane)

Names and Identifiers

IUPAC Name 1-(6,8-difluoro-2-methylquinolin-4-yl)-3-[4-(dimethylamino)phenyl]urea;hydrochloride
INCHI InChI=1S/C19H18F2N4O.ClH/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3;/h4-10H,1-3H3,(H2,22,23,24,26);1H
InChi Key DIHXPSGMLOETTI-UHFFFAOYSA-N
Canonical SMILES CC1=CC(=C2C=C(C=C(C2=N1)F)F)NC(=O)NC3=CC=C(C=C3)N(C)C.Cl
Isomeric SMILES CC1=CC(=C2C=C(C=C(C2=N1)F)F)NC(=O)NC3=CC=C(C=C3)N(C)C.Cl
Alternate CAS 1431697-90-3
PubChem CID 71576692
Molecular Weight 392.83

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilityH2O : 1 mg/mL (2.55 mM; ultrasonic and warming and heat to 60°C) DMSO : <1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

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