SB 431542

Item Number

S753351-GMP

Grouped product items
SKU	Size	Availability	Price	Qty
S753351-GMP-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,443.90

SB 431542 synthesized to cGMP guidelines

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Specifications & Purity

GMP, ≥99%

Storage Temp

Room temperature

Shipped In

Normal

Grade

GMP

Product Description

TGF Beta 1 (TGF-β1), ALK4 and ALK7 Inhibitor. Replaces SOX2 in reprogramming of fibroblasts to iPSCs

Names and Identifiers

IUPAC Name	4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
INCHI	InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChi Key	FHYUGAJXYORMHI-UHFFFAOYSA-N
Canonical SMILES	C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
Isomeric SMILES	C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
PubChem CID	4521392
Molecular Weight	384.39

Citations of This Product

1. Jinyue Zhu, Weiqing Wang, Xia Wu. (2020) Isorhynchophylline exerts anti-asthma effects in mice by inhibiting the proliferation of airway smooth muscle cells: The involvement of miR-200a-mediated FOXC1/NF-κB pathway. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 521 (1055). [PMID:31733831] [10.1016/j.bbrc.2019.10.178]
2. Meng Wang, Hui Li, Yaxin Zhao, Chuanfeng Lv, Guanghua Zhou. (2019) Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor‑β1‑mediated Smad and mitogen‑activated protein kinase signaling transductions in vivo and in vitro. Experimental and Therapeutic Medicine, 17 (1): (251-259). [PMID:30651790] [10.3892/etm.2018.6909]

References

1. Jinyue Zhu, Weiqing Wang, Xia Wu. (2020) Isorhynchophylline exerts anti-asthma effects in mice by inhibiting the proliferation of airway smooth muscle cells: The involvement of miR-200a-mediated FOXC1/NF-κB pathway. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 521 (1055). [PMID:31733831] [10.1016/j.bbrc.2019.10.178]
2. Meng Wang, Hui Li, Yaxin Zhao, Chuanfeng Lv, Guanghua Zhou. (2019) Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor‑β1‑mediated Smad and mitogen‑activated protein kinase signaling transductions in vivo and in vitro. Experimental and Therapeutic Medicine, 17 (1): (251-259). [PMID:30651790] [10.3892/etm.2018.6909]

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Basic Description