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SB 452533 - ≥98%(HPLC), high purity , CAS No.459429-39-1, Channel blocker of TRPV1

Moligand™
≥98%(HPLC)

CAS#: 459429-39-1
Formula: C₁₈H₂₂BrN₃O
Molecular Weight: 376.29
PubChem CID: 9842609

Item Number

S288655

Grouped product items
SKU	Size	Availability	Price
S288655-5mg	5mg	In stock	$117.90
S288655-10mg	10mg	In stock	$197.90
S288655-25mg	25mg	In stock	$385.90
S288655-50mg	50mg	In stock	$593.90
S288655-100mg	100mg	In stock	$890.90

Potent TRPV1 antagonist

View related series

TRPV1 Channel blocker

Basic Description

Synonyms	SB 452533\|459429-39-1\|SB452533\|SB-452533\|1-(2-bromophenyl)-3-{2-[ethyl(3-methylphenyl)amino]ethyl}urea\|N-(2-Bromophenyl)-N'-[2-[ethyl(3-methylphenyl)amino]ethyl]-urea\|n-(2-bromophenyl)-n'-[2-[ethyl(3-methylphenyl)amino]ethyl]urea\|n-(2-bromophenyl)-n'-{2-[
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent TRPV1 antagonist against capsaicin (pKb= 7.7), noxious heat and acid-mediated (pIC50= 7.0) receptor activation (pKi= 6.22 at the recombinant hTRPV1 receptor). Exhibits analgesic properties.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of TRPV1

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 1 Activities

Discover Target: TRPV1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-(2-bromophenyl)-3-[2-(N-ethyl-3-methylanilino)ethyl]urea
INCHI	InChI=1S/C18H22BrN3O/c1-3-22(15-8-6-7-14(2)13-15)12-11-20-18(23)21-17-10-5-4-9-16(17)19/h4-10,13H,3,11-12H2,1-2H3,(H2,20,21,23)
InChi Key	IFJYEGJUQIBBQV-UHFFFAOYSA-N
Canonical SMILES	CCN(CCNC(=O)NC1=CC=CC=C1Br)C2=CC=CC(=C2)C
Isomeric SMILES	CCN(CCNC(=O)NC1=CC=CC=C1Br)C2=CC=CC(=C2)C
WGK Germany	3
PubChem CID	9842609
Molecular Weight	376.29

PubChem CID

9842609

ChEMBL Ligand

CHEMBL120735

CAS Registry No.

459429-39-1

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
G2220207	Certificate of Analysis	Jun 02, 2022	S288655
G2220208	Certificate of Analysis	Jun 02, 2022	S288655
G2220209	Certificate of Analysis	Jun 02, 2022	S288655
G2220210	Certificate of Analysis	Jun 02, 2022	S288655
G2220211	Certificate of Analysis	Jun 02, 2022	S288655

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3
RIDADR	UN30779/PGIII

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